抗抑郁治疗对老年高血压降压疗效的影响  

The effects of antidepressant treatment on antihypertensive therapy in elderly patients

作　　者：李卫媛[1] 阮丽波[1] 

机构地区：[1]云南省第一人民医院老年病科,昆明650032

出　　处：《临床心血管病杂志》2011年第4期275-277,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨抗抑郁治疗对老年高血压患者降压疗效的影响。方法:观察85例老年高血压合并抑郁症状的患者随机分为2组,所有患者均给予钙拮抗剂(氨氯地平5mg/d)、血管紧张素转化酶抑制剂(贝那普利10mg/d),抗抑郁治疗组在此基础上加用帕罗西丁20mg/d。结果:抗抑郁治疗组其降压幅度,降压有效率,汉密尔顿抑郁量减分率均优于治疗前及对照组,差异显著有统计学意义(P<0.05)。结论:抗抑郁治疗可增强老年高血压合并抑郁患者的降压效果。Objective：To explore the effects of antidepressant treatment on antihypertensive therapy of elderly patients.Method：85 senile hypertensive patients with depression were randomly divided into A and B,two groups for study.Then 5 mg/d Amlidipine and 10 mg/d Benazepril were orally administrated to each group as basic antihypertensive medication.Besides,20 mg/d paroxetine was additionally given to group A.Result：Group A shows its patients＇ blood pressure of average reduction,effective rate of blood pressure reduction and Hamilton depression（HAMD） scale all have much better effects than pretherapy and group B,with obvious statistical significance（P0.05）.Conclusion：Antidepressant treatment may increase efficacy of antihypertensive therapy in elderly hypertensive patients with depression.

关 键 词：高血压 抑郁 帕罗西丁 

分 类 号：R544.1[医药卫生—心血管疾病]