NSAID-induced deleterious effects on the proximal and mid small bowel in seronegative spondyloarthropathy patients  

作　　者：Mihai Rimba■ Mǎdǎlina Marinescu Mihail Radu Voiosu Cristian Rǎsvan Bǎicu■ Simona Caraiola Adriana Nicolau Doina Ni■escu Georgeta Camelia Badea Magda Ileana Parvu 

机构地区：[1]Department of Gastroenterology, "N.Gh.Lupu" Clinic of Inter-nal Medicine, "Carol Davila" University of Medicine and Phar-macy, Colentina Clinical Hospital [2]Department of Internal Medicine, "N.Gh.Lupu" Clinic of Internal Medicine, "Carol Davila" University of Medicine and Pharmacy, Colen-tina Clinical Hospital [3]Department of Rheumatology, Colentina Clinical Hospital

出　　处：《World Journal of Gastroenterology》2011年第8期1030-1035,共6页世界胃肠病学杂志（英文版）

基　　金：Supported by CNCSIS-UEFISCSU, Romanian Ministry of Education and Research, project number PNII-IDEI 320/2007;part of a study registered on ClinicalTrials.gov with the number NCT00768950

摘　　要：AIM:To investigate the small bowel of seronegative spondyloarthropathy(SpA) patients in order to ascertain the presence of mucosal lesions.METHODS:Between January 2008 and June 2010,54 consecutive patients were enrolled and submitted to avideo capsule endoscopy(VCE) examination.Historyand demographic data were taken,as well as the history of non-steroidal anti-inflammatory drug(NSAID) consumption.After reading each VCE recording,a capsule endoscopy scoring index for small bowel mucosal inflammatory change(Lewis score) was calculated.Statistical analysis of the data was performed.RESULTS:The Lewis score for the whole cohort was 397.73.It was higher in the NSAID consumption subgroup(P = 0.036).The difference in Lewis score between NSAID users and non-users was reproduced for the first and second proximal tertiles of the small bowel,but not for its distal third(P values of 0.036,0.001 and 0.18,respectively).There was no statistical significant difference between the groups with regard to age or sex of the patients.CONCLUSION:The intestinal inflammatory involvement of SpA patients is more prominent in NSAID users for the proximal/mid small bowel,but not for its distal part.AIM：To investigate the small bowel of seronegative spondyloarthropathy（SpA） patients in order to ascertain the presence of mucosal lesions.METHODS：Between January 2008 and June 2010,54 consecutive patients were enrolled and submitted to avideo capsule endoscopy（VCE） examination.Historyand demographic data were taken,as well as the history of non-steroidal anti-inflammatory drug（NSAID） consumption.After reading each VCE recording,a capsule endoscopy scoring index for small bowel mucosal inflammatory change（Lewis score） was calculated.Statistical analysis of the data was performed.RESULTS：The Lewis score for the whole cohort was 397.73.It was higher in the NSAID consumption subgroup（P = 0.036）.The difference in Lewis score between NSAID users and non-users was reproduced for the first and second proximal tertiles of the small bowel,but not for its distal third（P values of 0.036,0.001 and 0.18,respectively）.There was no statistical significant difference between the groups with regard to age or sex of the patients.CONCLUSION：The intestinal inflammatory involvement of SpA patients is more prominent in NSAID users for the proximal/mid small bowel,but not for its distal part.

关 键 词：Videocapsule endoscopy Lewis score Non-steroidal anti-inflammatory drugs Small bowel mucosal injury SPONDYLOARTHROPATHY 

分 类 号：R681.5[医药卫生—骨科学]