内皮微颗粒与冠心病  

Endothelial Microparticles and Coronary Heart Disease

作　　者：夏金盈[1] 华奇峰[1] 李莹[1] 

机构地区：[1]同济大学附属东方医院心内科,上海市200120

出　　处：《中国动脉硬化杂志》2011年第2期160-164,共5页Chinese Journal of Arteriosclerosis

基　　金：上海市科委攻关项目(10411968000)

摘　　要：内皮微颗粒是内皮细胞激活或损伤时产生的膜性小囊泡,具有促进黏附、扩大炎症反应和诱导新生血管增生等作用。近年来的许多研究表明,内皮微颗粒与氧化应激、内皮功能紊乱、易损斑块破裂等密切相关,与冠心病的发生和发展过程密切相关。内皮微颗粒的发现为研究冠心病的发病机制开辟了新的研究平台,有望成为研究冠心病新的热点。Endothelial microparticles are submicron membrane vesicles shed from plasma membranes in response to endothelial cell activation or injury and play a major biological role in adhesion,inflammation and angiogenesis.Recent studies indicate that endothelial microparticles are involved in the development of coronary heart disease for their close association with oxidative stress,endothelial dysfunction and vulnerable plaque rupture.Thus,elucidating their role and their mechanisms of formation will bring new insights into the understanding of coronary heart disease.

关 键 词：内皮微颗粒 内皮功能障碍 冠心病 动脉粥样硬化 斑块不稳定 

分 类 号：R5[医药卫生—内科学]