银屑病皮损及正常人皮肤中Akt1,Akt2和Akt3的表达  

The Expression of Akt1,Akt2,Akt3 in the Lesions of Psoriasis Vulgaris

作　　者：蔓小红[1] 张晓艳[1] 李红艳[2] 徐波[2] 唐娟[1] 陈扬鑫[1] 潘琳[2] 

机构地区：[1]卫生部中日友好医院皮肤科,北京100029 [2]卫生部中日友好医院临床研究所,北京100029

出　　处：《中国皮肤性病学杂志》2011年第5期338-340,共3页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金资助项目(30872266);北京自然科学基金资助项目(7092094)

摘　　要：目的探讨Akt三种亚型Akt1,Akt2和Akt3的表达在寻常性银屑病发病中的意义。方法采用免疫组化法检测30例寻常性银屑病皮损及15例正常皮肤中Akt1,Akt2和Akt3的表达,并利用计算机图像采集与分析系统对免疫组化结果进行平均光密度测定。结果免疫组化结果显示,与正常人表皮相比,寻常性银屑病皮损中Akt1(0.2170±0.0144)和Akt2(0.2157±0.0150)的表达差异无统计学意义(P>0.05),而Akt3(0.2990±0.0165)的表达却明显高于正常皮肤,差异有统计学意义(P<0.01)。结论寻常性银屑病皮损内Akt活性的升高可能与Akt3的表达增强有关。Objective To investigate the significance of the expression of three isoforms of Akt in the pathogenesis of psoriasis. Methods ＇ Immunohistochemistry method was used to detect the expression of Akt1, Akt2, Akt3 in lesions from 30 patients with psoriasis vulgaris and skin from 15 normal people. The expression levels of Akt1, Akt2, Akt3 were analyzed by measurement of the average optical density of immunostaining. Results The expression of both Aktl （0. 2170 ±0.0144）. and Akt2（0. 2157 ±0.0150） in psoriatic lesions had no obvious differences compared with that of normal skin （P 〉 0.05, respectively）. However, the expression of Akt3 （0.2990 ± 0. 0165） in psoriatic lesions was significantly higher than that in normal skin （P 〈 0.01 ）. Conclusion The increased expression of Akt3 might be correlated to the elevation of phosphorylated Akt and Akt activity in psoriatic lesions.

关 键 词：AKT1 AKT2 Akt3 银屑病 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]