针刺对海洛因线索诱发成瘾者磁共振脑功能成像的影响  

Effect of Acupuncture on Heroin Cue-induced Functional Magnetic Resonance Images in Heroin-addicted Human Subjects

作　　者：宋小鸽[1] 李传富[2] 胡玲[1] 马宁[3] 王键[1] 李楠[3] 李西亮[1] 

机构地区：[1]安徽中医学院针灸经络研究所,合肥230038 [2]安徽省中医院影像中心,合肥230031 [3]中国科技大学生命科学院,合肥230026

出　　处：《针刺研究》2011年第2期121-127,共7页Acupuncture Research

基　　金：安徽省科技攻关项目(No.07010302205)

摘　　要：目的:观察线索诱发海洛因渴求相关的特异脑区及针刺足三里穴对这些脑区的影响。方法:14例海洛因依赖者在观看海洛因线索诱发、针刺足三里穴(60次/min,2 min)状态下,运用磁共振脑功能成像对海洛因线索诱发和针刺时脑区激活的程度进行比较,应用功能性神经图像分析AFNI软件包进行数据分析。结果:海洛因线索诱发时双侧额中回、左侧扣带回、双侧岛叶、枕叶皮层、左侧楔叶、小脑、双侧丘脑、右侧海马和右侧杏仁核等与渴求相关的脑区激活显著。针刺时左侧楔叶、小脑前上方、右侧前扣带回、右侧岛叶、丘脑、右侧海马回等脑区的激活程度减弱,与线索诱发相比较差异明显。结论:海洛因线索诱发可激活与渴求相关的奖赏、学习记忆、认知、情绪等脑区,而针刺足三里穴对与渴求相关的脑区具有一定的抑制作用。Objective To observe heroin cue-induced changes of cerebral functional magnetic resonance images （fMRI） and the effect of acupuncture of Zusanli （ST 36） on them under craving state in heroin-addicted volunteers. Methods Fourteen male volunteer heroin addicts were recruited in the present study. Brain images were acquired before, during （2 min） and after visualizing heroin （placed in a transparent glass mug） and acupuncture of Zusanli （ST 36） on a 1.5-T Siemens Symphony MRI system equipped with a standard head coil. Acupuncture stimulation was applied to bilateral Zusanli （ST 36） by manipulating a filiform needle at a frequency of about 60 cycles/min and an angle of about 180＊ for 2 min. The acquired neuroimaging data were analyzed by AlphaSim, AFNI. Results During heroin-visual stimulation, the markedly activated brain areas （increase of blood oxygen level-dependent signal） of fMRI were bilateral middle frontal gyrus, left cingulate gyrus, bilateral insula, occipital cortex, left cuneus, cerebellum, bilateral thalamus, right hippocampus and right amygdala etc. which are closely related to the human＇s craving psychological activities. When acupuncture given, meaning processing stronger sensory task, the heroin-addicted subjects showed apparent activation of the brain areas including the right anterior cingulate gyrus, right insula, thalamus, right hippocampal gyrus etc. which activation degrees were significant lower than those of heroin related visual stimulation. Conclusion Acupuncture of Zusanli （ST 36） can lessen heroin cue-induced activation degree of the brain areas involving psychological craving, suggesting that acupuncture is able to suppress the heroin addiction patients＇ drug abuse craving.

关 键 词：针刺 海洛因成瘾 海洛因线索 磁共振脑功能成像 

分 类 号：R245.311[医药卫生—针灸推拿学]