针刺调节细胞信号转导的研究及思考  

Progress of Studies on Effects of Acupuncture on Cellular Signal Transduction

作　　者：徐甜[1] 李忠仁[1] 

机构地区：[1]南京中医药大学,南京210042

出　　处：《针刺研究》2011年第2期150-154,共5页Acupuncture Research

基　　金：国家自然科学基金资助项目(30772836);国家重点基础研究"973"项目(2005CBJ-23306-8)

摘　　要：为了进一步阐明针刺作用机制,对于细胞信号转导的研究日趋深入。本文从针刺的物理信号传入,起效的效应分子G蛋白,第二信使环磷酸腺苷、Ca2+、三磷酸肌醇、二酰基甘油,信号转导通路有丝分裂原激活的蛋白激酶、Janus激酶-信号转导转录激活因子、一氧化氮-环磷酸鸟苷等及细胞信号转导网络方面出发,系统分析了针刺刺激引发的细胞信号转导机制。认为应关注结缔组织信号网的研究,并应重视研究各条转导通路相互之间的关系,提出对于整体信号转导网络的探索应是未来的研究方向。In order to elucidate the underlying mechanism of acupuncture in regulating different physiological functional activities at cellular level, abundant researches have been conducted on cellular signal transduction activities. The present article preliminarily analyzes acupuncture stimulation induced various cellular signaling pathways from the afferent physical signals of the regional mechanical stimulation at the acupoint, activation of receptors of the cellular membrane such as Guanine nucleotide bin- ding protein coupled receptors, etc., intracellular second messenger molecules including cAMP, Ca2＋ , inositol triphosphate, dia- cyl glycerol, etc., signal transduction pathways as mitogen-activated protein kinase, Janus kinase-signal transduction and tran- scription activator, nitrogen oxide-cyclic guanylic acid, etc., to the extremely complicated cellular signal transduction networks. In addition, the present paper also makes a discussion on the present developing situation of acupuncture research. It is possible that the connective tissue of the body surface will become a key point in the future research on acupuncture remedy. More attention should be paid to the interrelation among various intracellular signaling pathways and the network of cellular signal transduction in the research on acupuncture therapy for regulating a variety of physiological effects.

关 键 词：针刺 结缔组织网 细胞信号转导 效应机制 细胞信号网络 

分 类 号：Q257[生物学—细胞生物学]