精神压力对C3H/HeJ小鼠斑秃发病率的影响  

The Effect of Mental Stress on Alopecia Areata Incidence in C3H/HeJ Mice

作　　者：汤球[1] 蔡丽萍[1] 江鹏亮[1] 

机构地区：[1]第二军医大学实验动物中心,上海200433

出　　处：《实验动物与比较医学》2011年第2期105-107,共3页Laboratory Animal and Comparative Medicine

摘　　要：目的 研究精神压力对C3H/HeJ小鼠斑秃发病率的影响.方法 选取C3H/HeJ小鼠80只,随机分为4组,即精神压力组、药物诱导组、精神压力与药物诱导组和对照组,每组20只,干预后观察4个月,统计斑秃发病率,并比较各组差异.结果 精神压力组斑秃发病率为10%,对照组没有发生;精神压力与药物诱导组发病率为90%,药物诱导组发病率为60%,差异有统计学意义（P〈0.05）.结论 精神压力在药物诱导下显著提高C3H/HeJ小鼠斑秃发病率.Objective To study the effect of mental stress on the alopecia areata incidence in C3H/ HeJ mice. Methods Eighty C3H/HeJ mice were selected and randomly divided into 4 groups： mental stress group, drug-induced group, mental stress and drug-induced group, and control group, each group including 20 mice. Follow-up a period and observe the incidence of alopecia areata after intervention, and compare the differences among groups. Results The alopecia areata incidence of mental stress group was 10%, the control group did not occur; the incidence of mental stress and drug-induced group was 90%, incidence of drug-induced group was 60%, the difference was statistically significant （P〈0.05）. Conclusion The mental stress significantly increased the alopecia areata incidence of C3H/HeJ mouse.

关 键 词：精神压力 C3H/HeJ小鼠 斑秃 

分 类 号：R758.71[医药卫生—皮肤病学与性病学] R-332[医药卫生—临床医学]