活血通络颗粒对大鼠血液流变学及血栓形成的影响  

Effect of Huoxue Tongluo Granule on hemorrheology and thrombosis in rat

作　　者：张铭连[1] 解世朋[1] 石慧君[1] 李志金[1] 王浩[1] 常永业[1] 

机构地区：[1]河北省邢台市眼科医院河北省中医眼科研究所,邢台054001

出　　处：《中国中医眼科杂志》2011年第2期66-69,共4页China Journal of Chinese Ophthalmology

基　　金：河北省2009年科学技术研究与发展计划(09276418D-16)

摘　　要：目的通过观察活血通络颗粒对SD大鼠动脉-静脉旁路血栓形成、血液流变性的影响,探讨其治疗缺血性眼病的作用机理。方法将SD大鼠随机分为5组,分别为活血通络颗粒小、中、大剂量组,阿司匹林组,空白对照组,每组10只。将含有内置丝线的套管连通左颈外静脉与右颈总动脉,通过测定丝线上血栓的重量,观察活血通络颗粒对大鼠动-静脉旁路血栓形成的影响。另取48只大鼠随机分为6组,每组8只,分别为活血通络颗粒小、中、大剂量组、复方丹参片组、空白对照组、模型对照组。采用不可预知的慢性应激刺激及皮下注射射盐酸肾上腺素复加冰水浴等方法制作大鼠气滞血瘀模型,观察活血通络颗粒对气滞血瘀模型大鼠血液流变学指标的影响。结果活血通络颗粒对SD大鼠动-静脉旁路血栓的形成有明显的抑制作用(与空白对照组比较P<0.01);可降低气滞血瘀SD大鼠全血黏度值,具有一定的活血化瘀作用(与模型对照组比较P<0.05,P<0.01)。结论活血通络颗粒能够抑制血栓的形成,改善血液流变学指标。OBJECTIVE To study the influence of Huoxue Tongluo Granule on hemorrheology and thrombosis in rat so as to explore its mechanism.METHODS Fifty SD rats were randomly divided into five groups： low,medium and large dose of Huoxue Tongluo Granule groups,blank control group and acenterine group.After corresponding operation,thrombosis on the suture silk was measured to evaluate the effect of Huoxue Tongluo Granule on arterio-vein thrombogenesis.In the other experiment,48 SD rats were randomly divided into six groups： low,medium and large dose of Huoxue Tongluo Granule groups,compound salvia miltiorrhiza tablet group,blank control group and model control group.The qi stagnation and blood stasis rat model was established by unexpected chronic stress stimulus,adrenalin subcutaneous injection and ice water immersion.The whole blood viscosity was then determined.RESULTS Huoxue Tongluo Granule can interrupt the arterio-vein thrombogenesis（P0.05,P0.01）and decrease the whole blood specific viscosity of rat model（P0.05,P0.01）.CONCLUSIONS Huoxue Tongluo Granule has obvious effects on hemorrheology and thrombosis.

关 键 词：活血通络颗粒 缺血性眼病 药效学 

分 类 号：R285.5[医药卫生—中药学]