再生障碍性贫血中T-bet的表达及其对CD4^+ T细胞极化的调控  

Expression of T-bet and Its Regulation on CD4^+ T Cell Polarization in Aplastic Anemia——Review

作　　者：王海丽[1] 魏武[2] 

机构地区：[1]山西医科大学第二临床医学院血液内科,山西太原030001 [2]长治医学院附属和平医院,山西长治046000

出　　处：《中国实验血液学杂志》2011年第2期546-549,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金资助项目(编号30950015);山西省留学回国人员重点科研资助项目(编号2009-5)

摘　　要：再生障碍性贫血(aplastic anemia,AA)是一种以造血组织为靶细胞的自身免疫性疾病,其中T淋巴细胞介导的细胞免疫异常为AA发病机制中的关键环节,以Thl淋巴细胞数量增多和功能亢进为主要特征。近年来研究认为,T-bet是Thl细胞的特异性转录因子,是CD4+T淋巴细胞向Th1极化的关键因素,在AA患者中T-bet高表达,是AA发病机制中的重要环节。本文就T-bet及其与AA的关系,诸如AA患者中T-bet的表达,T-bet对CD4+T细胞极化的调控进行综述。Aplastic anemia（AA） is an autoimmune disease which take hematopoietic tissue as target cells.T lymphocyte-mediated cellular immune abnormality plays a key role in the pathogenesis of AA.Increase and hyperfunction of Thl lymphocytes are main feature of AA disease.The recent studies indicated that T-bet is Th1 cell-specific transcription factor,is crucial factor for polarization of CD4＋ T lymphocytes to Th1.High expression of T-bet in AA patients is an important link in pathogenesis of AA.In this article,T-bet and its relation with AA,including expression of T-bet in AA patients,the regulation of T-bet on polarization of CD4＋ T lymphocytes are reviewed.

关 键 词：再生障碍性贫血 T淋巴细胞 CD4+T细胞 THL细胞 T-BET 

分 类 号：R556.5[医药卫生—血液循环系统疾病]