A molecular switch of ＂Yin and Yang＂： S-glutathionylation of eNOS turns off NO synthesis and turns on superoxide generation  

作　　者：Dayue Darrel DUAN Chiu-yin KWAN 

机构地区：[1]The Laboratory of Cardiovascular Phenomics, Center of Biomedical Research Excellence, and the Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada 89557, USA [2]Vascular Biology Research Group, Research Institute of Basic Medical Sciences and Center for Faculty Development, China Medical University, Taichung, Taiwan, China

出　　处：《Acta Pharmacologica Sinica》2011年第4期415-416,共2页中国药理学报（英文版）

摘　　要：Nitric oxide （NO） is a short-lived free radical produced endogenously in biological tissues by nitric oxide synthases （NOSs）. Three NOS isoforms, namely NOS1 or neuronal NOS （nNOS）, NOS2 or inducible NOS （iNOS）, and NOS3 or endothelial NOS （eNOS） are present in most cell types,Nitric oxide （NO） is a short-lived free radical produced endogenously in biological tissues by nitric oxide synthases （NOSs）. Three NOS isoforms, namely NOS1 or neuronal NOS （nNOS）, NOS2 or inducible NOS （iNOS）, and NOS3 or endothelial NOS （eNOS） are present in most cell types,

分 类 号：Q347[生物学—遗传学] O641.3[理学—物理化学]