丹皮酚双席夫碱的合成及其抗氧化活性研究  

Synthesis and Anti-oxidation Activity of Paeonol Schiff Base Derivatives

作　　者：康建军[1] 陈莉敏[2] 林友文[2] 

机构地区：[1]福建医科大学药学院药学实验中心,福州350004 [2]福建医科大学药学院药物化学系,福州350004

出　　处：《福建医科大学学报》2011年第1期26-28,共3页Journal of Fujian Medical University

基　　金：福建省自然科学基金(2009J01158);福建医科大学教授学术发展基金计划基金(JS09004)

摘　　要：目的合成并表征三个丹皮酚双席夫碱,初步研究其抗氧化活性。方法利用丹皮酚与水合肼、乙二胺、1,3-丙二胺反应,分别合成目标化合物双（2’-羟基-4’-甲氧基-α-甲基苄基）-二亚胺（A1）、双（2’-羟基-4’-甲氧基-α-甲基苄基）-乙二亚胺（A2）、双（2’-羟基-4’-甲氧基-α-甲基苄基）-1,3-丙二亚胺（A3）;用IR1、HNMR和MS进行表征,用邻苯三酚法进行抗氧化活性筛选。结果合成了A1~A3三个丹皮酚双席夫碱;三者均具有抗氧化活性,且随着浓度的增大而增强。结论目标化合物A3对自由基清除活性好于丹皮酚。Objective To synthesize three Paeonol Schiff base derivatives and evaluate their anti-oxidation activities.Methods Three Paeonol Schiff base derivatives were synthesized by coupling Paeonol with hydrazine hydrate,quadrol,1,3-propanediamine,respectively.These complexes were characterized by IR spectra,1HNMR,MS and screened by anti-oxidation model.Results Three Paeonol Schiff base derivatives were synthesized and were all anti-oxidatively active in a dose-dependent manner.Conclusion The targete compound A3 perform better anti-oxidation activity than Paeonol and is worthy of further study.

关 键 词：牡丹酚 希夫碱类 抗氧化剂 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]