血管炎患者抗中性粒细胞胞浆抗体及中药的干预作用  

Determination of Antineutrophil Cytoplasmic Antibodies and Intervention of Traditional Herbs in Patients with Vasculitis

作　　者：李艳[1] 李坤[2] 崔炎[3] 

机构地区：[1]河南中医学院第一附属医院核医学科,郑州450000 [2]南京大学医学院附属鼓楼医院血管外科,南京210008 [3]河南中医学院第一附属医院周围血管科,郑州450000

出　　处：《中国中西医结合外科杂志》2011年第2期171-173,共3页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：国家十一五支撑课题(2007BAT10801-053)

摘　　要：目的:研究抗中性粒细胞胞浆抗体(ANCA)的检测对血管炎诊断的意义及中药对其影响。方法:间接免疫荧光法检测ANCA相关小血管炎(AASV)组和其他血管炎组ANCA的水平,并对AASV组患者进行通脉祛风汤治疗干预。结果:AASV组的ANCA检测阳性率明显高于其他血管炎组,通脉祛风汤能显著降低AASV疾病的ANCA的阳性率和复发率。结论:ANCA的检测对AASV的诊断具有较高的特异性,中医药对AASV有良好的干预作用。Objective To study the clinical significance of antineutrophil cytoplasmic antibodies（ANCA） and the impact of traditional herbs in patients with vasculitis.Methods The serum ANCA of 38 patients with ANCA associated systemic vasculitis（AASV） and that of 22 patients with other vasculitis were detected by indirect immunofluorescence.AASV group was intervented with Tongmai Qufeng（通脉祛风） decoction.Results The positive rate of ANCA in AASV patients was significantly higher than those in other vasculitis group.Tongmai Qufeng decoction could reduce the positive rate of ANCA and recidivation rate of AASV.Conclusion The determination of serum ANCA can be used as a high specific serum maker for diagnosis of vasculitis,and traditional herbal drugs shows a beneficially therapeutic effect on AASV.

关 键 词：抗中性粒细胞胞浆抗体 血管炎 通脉祛风汤 

分 类 号：R654.4[医药卫生—外科学]