黑皮质素系统对骨代谢影响的研究进展  

Progress in the effect of melanocortin system on bone metabolism

作　　者：李建周[1] 金勇君[1] 

机构地区：[1]滨州医学院附属医院内分泌科,滨州医学硕士研究生256603

出　　处：《医学研究生学报》2011年第4期441-444,共4页Journal of Medical Postgraduates

基　　金：山东省中青年科学家科研奖励基金(BS2010yy002)

摘　　要：骨质疏松(osteoporosis,OP)是由于破骨细胞的骨吸作用收与成骨细胞的骨形成作用所形成的骨重建过程失衡所致。黑皮质素系统由促黑素(melanocyte-stimulating hormone,MSH)、促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)、黑皮质素受体(melanocortin receptor,MCR)、内源性黑皮质素拮抗剂及2种辅助蛋白组成。近年来,促黑素与骨代谢相关性研究逐渐受到重视,文中就黑皮质素系统对骨代谢的影响作一综述。Osteoporosis,caused by the imbalance of the process of bone remodeling,is occurred in the process of osteoclastic bone resorption and bone formation of osteoblasts.The melanocortin system consists of melanocyte-stimulating hormone,adrenocorticotropic hormone,melanocortin receptors,endogenous melanocortin antagonists and two ancillary proteins.Recently more and more scholars pay attention to the study of the effect of melanocortin system on bone metabolism.This review summarizes some published works.

关 键 词：黑皮质素系统 骨代谢 促黑素 黑皮质素受体 

分 类 号：R681[医药卫生—骨科学]