降糖药物对新发2型糖尿病患者胫前动脉弹性影响的初步探讨  

Preliminary study on effects in elasticity of anterior tibial artery in new patients with type 2 diabetes caused by medicines of reducing blood sugar

作　　者：邹春鹏[1] 焦岩[2] 赵雅萍[1] 黄品同[1] 胡榕[1] 吴笑英[3] 吴朝明[3] 

机构地区：[1]温州医学院附属第二医院超声科,325027 [2]温州市第三人民医院妇产超声科 [3]温州医学院附属第二医院内分泌科,325027

出　　处：《中华超声影像学杂志》2011年第4期334-337,共4页Chinese Journal of Ultrasonography

基　　金：温州市科技局计划项目（Y20090304）

摘　　要：目的探讨降糖药物对新发2型糖尿病患者胫前动脉弹性的影响。方法随机选取新发2型糖尿病患者100例，分为对照组50例和病例组50例。计算胫前动脉的应变-血压指数（SBPI），所有患者服用降糖药物6个月后再次计算胫前动脉的SBPI，并进行组间和组内对比分析。结果对照组胫前动脉SBPI治疗后高于治疗前（P〈0．05）。病例组胫前动脉SBPI治疗前后比较差异无统计学意义（P〉0．05）。病例组胫前动脉SBPI在治疗前和治疗后均低于对照组（P〈0．05）。结论降糖药物对不合并血管并发症的新发2型糖尿病患者胫前动脉弹性有较好的保护作用。Objective To investigate the effects in elasticity of anterior tibial artery in new patients with type 2 diabetes caused by medicines of reducing blood sugar. Methods One hundred patients with type 2 diabetes were involved. The patients were divided into control group（50 cases） and case group（50 cases） according the vascular complications （including macroangiopathy and microangiopathy）. Maxmum of circumferential strain（CSmax） of anterior tibial artery was acquired through strain and strain rate imaging. Local blood pressure which included local systolic blood pressure（LSBP） and local diastolic blood pressure （LDBP） of anterior tibial artery was measured at the same time. Strain-blood pressure index（SBPI） of anterior tibial artery was calculated, SBPI = CSmax/[ （LSBP- LDBP）/LDBP] × 100%. It took six months for each patient to take medicines of reducing blood sugar. Then SBPI of anterior tibial artery was calculated again. Parameters were compared inter- and intra-groups. Results SBPI of anterior tibial artery after therapy was higher than that before therapy in control group（ P〈0.05）. There was no significant difference between SBPI of anterior tibial artery before therapy and that after therapy in case group（ P 〉0.05）. SBPI of anterior tibial artery in case group was lower than that in control whatever before and after therapy（ P〈0.05）. Conclusions The protection of medicines of reducing blood sugar on elasticity of anterior tibial artery in new diabetic patients without vascular complications was better.

关 键 词：超声检查 糖尿病 2型 胫前动脉 弹性 降血糖药 

分 类 号：R587.1[医药卫生—内分泌]