激光消融正常活体兔肝的超声表现及影响因素  

Ultrasound performance and related factors on the role of normal living rabbit＇s liver by laser ablation

作　　者：闫丽[1] 周晓东[1] 何光彬[1] 关军[2] 郑敏娟[1] 孟欣[1] 张苗苗[1] 周印[1] 

机构地区：[1]第四军医大学西京医院超声科,西安710032 [2]吉林省梅河口市中心医院电诊科

出　　处：《中华超声影像学杂志》2011年第4期348-350,共3页Chinese Journal of Ultrasonography

摘　　要：目的探讨激光消融活体兔肝的超声表现及影响因素。方法用Eeholaser集成激光介入超声系统消融正常兔肝，观察消融灶坏死程度、病理改变及解剖表现。结果消融灶呈类椭圆形，二维表现为中心规则强回声及周边稍强回声区，后方有轻度声衰减。超声造影显示消融灶呈“充盈缺损区”。解剖后，肉眼观消融灶中间为碎渣样碳化区，周边为褐白色样坏死区。HE染色显示消融灶中心呈“空洞样”无染色剂浸染区，周边呈不规则无核红染区，外围可见浸润的炎性细胞。不同功率及时间对消融效果及消融范围有影响且消融灶的大小与功率和时间呈正相关；3W10min组和5W6min组消融范围稳定、可导致消融区组织的完全坏死且两组间的消融范围差异有统计学意义（t=6．78，P〈0．05）。结论激光消融对活体兔肝能造成快速、精准、有效、安全的凝固性坏死，消融灶的大小与功率和时间呈正相关。Objective To explore the ultrasound performance and related factors on the role of normal living rabbit＇s liver by laser ablation. Methods The rabbit＇s liver tissue were ablated by Echolaser integrated laser interventional ultrasound system, and the necrosis of the lesion and performance of pathology and anatomy were observed. Results The outline of the lesion was ellipse like. The twodimensional US showed regular hyperecho area in the center, mild strong echo in the peripheral and mild attenuation backward. Contrast enhanced ultrasound （CEUS） showed a ＂filling defect＂ of contrast media in the ablated area. After dissection, the center of the lesion was slag-like carbon, the peripheral was necrosis area;HE staining showed：the center of the lesion was cavity like and dye-free, peripheral area was irregular red staining, the surrounding area was infiltrative inflammatory cells. Different power and time leaded to differences of the ablative effect and lesion size：the more power and time, the bigger of the ablative size. The ablative effect and lesion size was stable in 3 W 10 min and 5 W 6 min groups and caused the complete necrosis of the zone, there existed statistical differences among the two groups. Conclusions Laser ablation can cause fast,precise,effective and safe necrosis of the liver tissue,and the more power and time,the bigger of the ablative size.

关 键 词：超声检查 微气泡 激光凝固术 肝 

分 类 号：R445.1[医药卫生—影像医学与核医学]