血清高迁移率蛋白B1水平与脓毒症病死率的关系及其机制  

Relationship and mechanism between the serum level of HMGB1 and the mortality rate in patients with sepsis

作　　者：马玉东[1] 白霞[2] 于慧超[1] 孙宝山[1] 宋岩[1] 

机构地区：[1]沈阳医学院奉天医院ICU科,辽宁省沈阳110024 [2]中国医科大学基础医学院生理学教研室

出　　处：《中国基层医药》2011年第9期1153-1155,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：辽宁省教育厅资助项目（2008727）

摘　　要：目的 探讨高迁移率蛋白B1（HMGB1）与脓毒症患者病死率的关系及其可能机制.方法 测定48例脓毒症患者血清HMGB1、超氧化物歧化酶（SOD）和丙二醛（MDA）的变化并记录患者转归.结果 发病后,死亡组和存活组患者血清HMGB1水平均逐渐上升,72 h达高峰.死亡组患者血清HMGB1水平明显高于存活组（12和24 h除外）（t=6.07、6.20、24.43,均P＜0.05）.12、24、48和72 h死亡组患者血清SOD活力均明显低于存活组（t=10.24、20.61、11.67、33.33,均P＜0.05）,所测时间点死亡组患者血清MDA水平均明显高于存活组（t=26.06、22.17、23.86、9.49、5.95,均P＜0.05）.HMGB1水平与MDA水平成显著正相关.结论 血清HMGB1水平升高可能是脓毒症患者病死率增加的重要原因,氧化抗氧化系统失衡可能是HMGB1升高的原因之一.Objective To investigate the relationship and mechanism between the serum level of high mobility group box protein-1（HMGB1）and the mortality rate in patients with sepsis.Methods The serum levels of HMGB1,superoxide dismutase（SOD）and malondialdehyde（MDA）in 48 patients with sepsis were determined.The clinical outcomes in those patients were recorded and anlyzed.Results After the onset of sepsis,the serum HMGB1 levels of both death group and survival group were increased gradually and peaked at 72h after the onset of the disease.The semm HMGB1 levels of death group were much higher than those of survival group except at 24h（t=6.07,6.20,24.43,all P〈0.05）.The activity of serum SOD of death group was markedly lower than that of survival group at 12h,24h,48h and 72h（t=10.24,20.61,11.67,33.33,all P〈0.05）,and the level of serum MDA of death group was significantly higher than those of survival group at all time points（t=26.06,22.17,23.86,9.49,5.95,all P〈0.05）.There was a significantly positive correlation between the serum HMGB1 and MDA level.Conlusioa The increase in serum HMGB1 level may be the important reasoll for the increased mortality rate in patients with sepsis;Oxidant/antioxidant imbalance may be olle reason for the increase in serum HMGB1 level.

关 键 词：高迁移率蛋白-1 超氧化物歧化酶 丙二醛 脓毒症 

分 类 号：R45[医药卫生—治疗学]