糖尿病心脏病患者血浆心肌营养素-1水平与心功能的关系  

Clinical research on correlation between CT-1 and cardiac function in patients with diabetic cardiopathy

作　　者：林楚佳[1] 林少达[1] 黄少薇[1] 苏广瑞[1] 

机构地区：[1]汕头大学医学院第一附属医院内分泌科,广东省汕头515041

出　　处：《中国基层医药》2011年第9期1156-1158,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省汕头市科技计划项目（汕府科[2009]70号）

摘　　要：目的 探讨糖尿病心脏病患者血浆心肌营养素-1（CT-1）的变化及与心功能的关系.方法 应用BSA-ELISA法测定健康对照者、2型糖尿病患者及糖尿病心脏病患者血浆CT-1水平,观察其与心功能的关系.结果 三组间血浆CT-1水平差异均有统计学意义（均P＜0.05）,糖尿病心脏病组血浆CT-1水平均显著高于2型糖尿病组及对照组（均P＜0.01）;2型糖尿病组高于对照组（P＜0.01）.糖尿病心脏病患者随着心功能的下降,血浆CT-1浓度逐步升高.血浆CT-1水平与左室射血分数（r=0.669,P＜0.01）、左心房内径（r=0.528,P＜0.01）、二尖瓣E峰流速（r=0.502,P＜0.01）、磷酸肌酸同工酶（r=0.312,P＜0.01）、甘油三酯（r=0.187,P＜0.05）、舒张压（r=0.158,P＜0.05）相关;多元逐步回归分析发现影响血浆CT-1水平的最显著因素为左室射血分数、左心房内径.结论 血浆CT-1浓度是反映糖尿病心脏病心衰严重程度的敏感指标,有助于糖尿病心脏病的早期诊断.Objective To study the eorrelation between the plasma cardiotrophin-1（CT-1）level and cardiac function of patients with diabetic cardiopathy.Methods Using the Biotin-StreptAvidin-enzyme-linked immunosorbent assay（BSA-ELISA）,the level of plasma CT-1 jn 35 normal controls,40 patients with type 2 diabetes and 60 patients with diabetic cardiopathy was measured.The relation to heart function was observed.Results The difference of plasma CT-1 level in the three groups was significant（all P〈0.05）.The level of plasma CT-1 in diabetic cardiopathy group was apparently higher than that of type 2 diabetes group and normal controls（all P〈0.01）;The level in type 2 diabetes group was significantly higher than that of normal controls（P〈0.01）.The level of plasma CT-1 elevated with the worsening of heart failure（NYHA classification）.The level of plasma CT-1 was correlated with EF（r=0.669,P〈0.01）;LAD（r=0.528,P〈0.01）;PVE（r=0.502,P〈0.01）;CK-MB（r=0.312,P〈0.01）;TG（r=0.187,P〈0.05）;DBP（r=0.158,P〈0.05）o Stepwise regression analysis revealed that EF and LAD were the most significant agents affecting the plasma CT-1.Conclusion The plasma CT-1 level could reflect the state of cardiac function of diabetic cardiopathy patient,it could help to diagnose diabetic cardiopathy earlier.

关 键 词：糖尿病 心脏病 心肌营养素-1 心功能 

分 类 号：R587[医药卫生—内分泌] R541[医药卫生—内科学]