不同剂量氨茶碱用于小儿哮喘的疗效及安全性研究  被引量:11

Study on the effectiveness and safety of different doses of Aminophylline in children with asthma

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作  者:赵云红[1] 

机构地区:[1]贵州省遵义医院儿科,贵州遵义563002

出  处:《中国妇幼保健》2011年第14期2136-2138,共3页Maternal and Child Health Care of China

摘  要:目的:探讨不同剂量氨茶碱在小儿哮喘中的效果及安全性。方法:选择2009年7月~2010年7月期间,该院收治的中、轻度小儿哮喘患儿98例,随机将患者分成高剂量组和低剂量组,各49例。高剂量组氨茶碱5 mg/kg,低剂量组氨茶碱2 mg/kg。在治疗7天后对患者的病情进行疗效评估,并在整个治疗过程中随时记录患儿所出现的不良反应。对两组患者临床疗效,临床症状消失时间(包括哮喘消失时间、咳嗽消失时间、呼吸困难消失时间),不良反应的发生率(包括恶心、腹痛和烦躁不安等)进行临床观察。结果:与高剂量组相比,低剂量组显效率和症状评分的减少率明显提高,无效率明显降低,哮喘消失时间、咳嗽消失时间以及呼吸困难消失时间均明显缩短,差异亦具有统计学意义(P<0.05)。两组患者在用药期间,均有少数患者在治疗早期发生了恶心、腹痛、烦躁不安等不良反应,但治疗一段时间后症状基本消失,均可维持继续治疗。与高剂量组相比,低剂量组恶心、腹痛以及烦躁不安等不良反应的发生率均明显下降,差异具有统计学意义(P<0.05)。结论:小剂量的氨茶碱对处于急性发作期的哮喘患儿具有安全有效的治疗效果,在临床上具有一定的应用价值。Objective:To study the effectiveness and safety of different doses of Aminophylline in children with asthma.Methods:98 children with mild asthma were selected in our hospital from July 2009 to July 2010 and randomly divided into high dose group(49 cases)and low dose group(49 cases).5mg/kg Aminophylline was used in high dose group,2mg/kg Aminophylline was used in low-dose group.The effect was evaluated in 7 days after the treatment.The adverse reaction of the children was recorded at any time throughout the treatment process.Clinical efficacy and disappeared time of clinical symptoms(including asthma,cough,breathing) and rate of adverse reaction(including nausea,abdominal pain,irritability and other symptoms) of the two groups were observed.Results:Compared with the high dose group,the disappearance times of asthma,coughing and breathing difficulties were significantly shortened in the low dose group,the difference was significant(P0.05).During the treatment,few patients taken place nausea,abdominal pain,irritability and other adverse reactions in both groups,but the symptoms disappeared after a period of treatment time,the patients could remain for further treatment.Compared with the high dose group,the rate of nausea,abdominal pain and irritability and other adverse reactions decreased significantly in the low dose group,the difference was significant(P0.05).Conclusion:Small doses Aminophylline is safe and effective for the treatment of the children in the acute attack of asthma,and it has a certain value for clinical application.

关 键 词:氨茶碱 小儿哮喘 疗效 安全性 

分 类 号:R725.6[医药卫生—儿科]

 

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