c-kit及其配体干细胞因子在子宫内膜异位症中的表达及意义  

Expressions and significances of C-kit and its ligand-stem cell factor in endometriosis

作　　者：张平[1,2] 张怡[1] 戴芙蓉[1] 胡华利[1] 

机构地区：[1]中南大学湘雅医院妇产科,湖南长沙410008 [2]深圳龙岗中心医院妇产科

出　　处：《中国妇幼保健》2011年第14期2187-2190,共4页Maternal and Child Health Care of China

摘　　要：目的:探讨c-k it受体及干细胞因子(stem cell factor,SCF)在子宫内膜异位症(Endom etriosis,EM s)患者的异位和在位内膜组织中的表达。方法:采用免疫组化SABC法检测32例EM s患者异位内膜(异位内膜组)及在位内膜组织(在位内膜组)c-k it和SCF的表达,并与30例非EM s患者在位内膜(对照组)进行比较。结果:①异位和在位内膜组中,c-k it阳性表达平均光密度(MOD)分别为0.42±0.09和0.37±0.07,两者比较差异无统计学意义(P>0.05),但均高于对照组的0.28±0.07(P<0.05)。②异位和在位内膜组中,SCF阳性表达分别为0.27±0.07和0.24±0.09,两者比较差异无统计学意义(P>0.05),均高于对照组的0.15±0.04(P<0.05)。③c-k it和SCF在异位内膜组增生期和分泌期比较差异无统计学意义(P>0.05);在在位内膜组和对照组的分泌期高于增生期(P<0.05);c-k it和SCF在位内膜组分泌期和增殖期的表达均高于对照组同期水平(P<0.05)。④c-k it和SCF在异位内膜组Ⅰ/Ⅱ期与Ⅲ/Ⅳ期中的表达差异无统计学意义(P>0.05)。结论:c-k it/SCF在内异症患者异位和在位内膜中的表达增强,提示c-k it/SCF可能在子宫内膜异位症的发生、发展中起重要作用。Objective：To explore the expressions of c-kit receptor and stem cell factor（SCF） in ectopic endometrium and ectopic endometrium of patients with endometriosis.Methods：Immunohistochemical SABC method was used to detect the expression levels of c-kit and SCF in ectopic endometrium（eutopic endometrium group） and eutopic endometrium（eutopic endometrium group） of 32 patients with endometriosis,then the results were compared to those of eutopic endometrium of 30 cases without endometriosis（control group）.Results：The mean optical densities（MODs） of c-kit positive expression in ectopic endometrium group and eutopic endometrium group were（0.42±0.09） and（0.37±0.07）,respectively,there was no significant difference between the two groups（P0.05）,but the MODs in the above-mentioned groups were significantly higher than that in control group（0.28±0.07）（P0.05）.The positive expression levels of SCF in ectopic endometrium group and eutopic endometrium group were（0.27±0.07） and（0.24±0.09）,respectively,there was no significant difference between the two groups（P0.05）,but the positive expression levels of SCF in the above-mentioned groups were significantly higher than that in control group（0.15±0.04）（P0.05）.In ectopic endometrium group,there was no significant difference in expression levels of c-kit and SCF between proliferative phase and secretory phase（P0.05）;in eutopic endometrium group and control group,the expression levels of c-kit and SCF at secretory phase were significantly higher than those at proliferative phase（P0.05）.At proliferative phase and secretory phase,the expression levels of c-kit and SCF in eutopic endometrium group were significantly higher than those in control group（P0.05）.In ectopic endometrium group,there was no significant difference in expression levels of c-kit and SCF between stage Ι/Ⅱ and stage Ⅲ/Ⅳ（P0.05）.Conclusion：Over-expressions of c-kit and SCF in ectopic endometrium and eutopic endometrium of the p

关 键 词：子宫内膜异位症 C-KIT受体 干细胞因子 

分 类 号：R711.71[医药卫生—妇产科学]