酰基吡唑啉酮希夫碱及配合物的合成、结构及生物活性  

Synthesis Method,Structure and Biological Activity of Acylpyrazolone Schiff Base and Its Complexes

作　　者：李鹏[1] 李锦州[1] 

机构地区：[1]哈尔滨师范大学化学化工学院,黑龙江哈尔滨150025

出　　处：《化学与粘合》2011年第3期43-47,共5页Chemistry and Adhesion

基　　金：黑龙江省自然科学基金项目(编号:B201004);哈尔滨师范大学科技发展预研项目(编号:08XYG-12)

摘　　要：综述了酰基吡唑啉酮希夫碱及配合物的合成、结构和生物活性。介绍了非水溶剂法、固相合成法、水相合成法、溶剂热合成法等配合物合成方法。分析了酰基吡唑啉酮希夫碱参与过渡金属、稀土金属配位成键的方式,以及相应配合物空间构型为四面体、平面正方形、八面体、十二面体的结构关系。讨论了标题化合物对金黄葡萄球菌、枯草杆菌、大肠杆菌等的抑制作用。The synthesis method, structure and biological activity of acylpyrazolone Schiff base and its metal complexes was reviewed. The nonaqueous solvent method, the solid phase synthetic, water phase synthetic and the solvent thermal synthetic methods were introduced. The coordinating mode of aeylpyrazolone Schiff base with transition metal and rare metal ion and the structures of＂ spatial configuration were analyzed, such as tetrahedron, planar square, octahedral, dodecahedron. The antibacterial activities of title compounds against S. aureus, B. subtillis, E. coli, etc were also discussed.

关 键 词：酰基吡唑啉酮 希夫碱 配合物 晶体结构 抗菌活性 

分 类 号：TQ421.12[化学工程]