胃癌术后患者预后相关因素分析  

Related factors for prognosis of gastric cancer patients after operation

作　　者：刘利利[1] 韩颖[2] 路长宇[3] 胡守喜[4] 杜晓辉[1] 

机构地区：[1]解放军总医院普通外科研究所,北京100853 [2]邯郸市第一医院中西医结合内科,邯郸056000 [3]北京市门头沟区医院外科,北京102300 [4]山西省肿瘤医院特诊科,太原030013

出　　处：《军医进修学院学报》2011年第6期584-587,共4页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的探讨性别、年龄、肿瘤临床TNM(T肿瘤大小、N淋巴结转移、M远处转移)分期、化疗及危重病人预警蛋白质(LGT)指纹表达等与胃癌术后患者预后的关系。方法选取2008年6月-2009年6月收治的首次入院并行手术治疗的胃腺癌患者125例,选择性别、年龄、肿瘤临床TNM分期、化疗、LGT蛋白质指纹表达等指标,用单因素和多因素分析的方法研究其对患者生存的影响。结果单因素分析中肿瘤临床TNM分期、LGT丰度、峰型均为胃癌患者术后生存的影响因素。将上述诸相关参数进行COX比例风险回归模型分析,得出TNM分期、LGT蛋白质指纹丰度及峰型是影响胃癌术后患者生存的独立因素,按其影响大小依次排序为:TNM分期、LGT峰型、LGT丰度。结论肿瘤临床TNM分期、LGT峰型、LGT丰度是影响胃癌患者术后生存的独立因素。Objective To study the correlation between gender and age of gastric cancer patients,clinical TNM stage,chemotherapy,lost goodwill target（LGT） protein fingerprints and prognosis of gastric cancer patients after operation.Methods One hundred and twenty-five patients with gastric adenocardnoma admitted to our hospital in June 2008-June 2009 were enrolled in this study.Effect of their gender,age,TNM stage,chemotherapy,and LGT protein fingerprints on their survival time after operation was analyzed by single and multiple variable analyses.Results Single factor analysis showed that TNM stage,peak types and abundance of LGT protein fingerprints were the significant prognostic factors of the survival time of gastric cancer patients after operation.Multiple factor analysis showed that TNM stage,abundance and peak types of LGT protein fingerprints were the independent factors for the survival time of gastric cancer patients after operation in Cox ratio risk regression model.Conclusion TNM stage,abundance and peak types of LGT are the independent prognostic factors for the survival time of gastric cancer patients after operation.

关 键 词：胃癌 生存分析 LGT蛋白质指纹 

分 类 号：R73[医药卫生—肿瘤]