阿托伐他汀与辛伐他汀调脂疗效比较的系统评价  

System Evaluation of Lipid-regulatory Effect of Atorvastatin and Simvastatin

作　　者：何松 吴斌[2] 叶飞[3] 夏荣松 

机构地区：[1]解放军第91中心医院药剂科,河南焦作454003 [2]四川大学华西药学院 [3]四川大学华西医院药剂科

出　　处：《中国药师》2011年第5期692-694,共3页China Pharmacist

摘　　要：目的:评价阿托伐他汀与辛伐他汀调血脂的疗效。方法:电子检索CNKI、万方数据库、维普数据库、pubmed中关于阿托伐他汀与辛伐他汀调脂疗效比较的随机对照试验,采用Endnot X3去重及RevMan 5.0软件进行Meta分析。结果:阿托伐他汀与辛伐他汀在降低三酰甘油(TG)、血清总胆固醇(TC)指标方面差异有统计学意义[MD=-0.57,95%CI(-1.07,-0.07),P<0.05]、[MD=-0.61,95%CI(-0.99,-0.24),P<0.05];而降低低密度脂蛋白(LDL)、升高高密度脂蛋白(HDL)等比较,差异无统计学意义[MD=-0.24,95%CI(-0.53,0.04),P>0.05]、[MD=-0.01,95%CI(-0.13,0.11),P>0.05]。两药的不良反应比较,差异也无统计学意义[RR=1.05,95%CI(0.69,1.62),P>0.05]。结论:阿托伐他汀在降低TG、TC的指标明显优于辛伐他汀,在升高HDL、降低LDL的指标差异无统计学意义,两药不良反应相当。Objective： To compare the lipid-regulatory effect of atorvastatln and simvastatin. Method： The literatures of random- ized controlled trials on the lipid-regulatory effect of atorvastatin and simvastatin were retrieved from PubMed, CNKI, VIP and Wangfang databases,and the Endnot X3 software was applied to remove the repetition and recta-analysis was conducted to compare the effect of atorvastatin and simvastatin using RevMan 5.0 software. Result： The meta-analysls showed that atorvastatin and simvatatin could reduce TG and TC with significant differences, [ MD = -0. 57,95% CI（ - 1. 07, -0. 07） ,P 〈 0. 05 ] and [ MD = -0. 61,95% CI（ -0.99, - 0. 24） ,P 〈0. 05 ]. However, the effect of reducing LDL and rising HDL of atorvastatin and simvastatin had no significant differences, [ MD = - 0.24,95% CI （ - 0. 53,0. 04 ）, P 〉 0. 05 ] and [ MD = - 0. 01,95 % CI （ - 0. 13,0. 11 ）, P 〉 0. 05 ], and the ADR of the two medicines was similar, [ RR = I. 05,95% CI（0. 69,1. 62 ） ,P 〉0. 05 ]. Conclusion： Atorvastatin is better than simvastatin in reducing TG and TC but with the similar effects on HDL, LDL and ADR.

关 键 词：辛伐他汀 阿托伐他汀 高脂血症 系统评价 

分 类 号：R972.6[医药卫生—药品]