强碱性阴离子交换树脂催化合成邻乙酰乙酰氨基苯甲醚  

Study on Synthesis of o-Methoxy Acetoacetanilide with Strong Base Anion Exchange Resin

作　　者：王树清[1] 高崇[1] 

机构地区：[1]南通大学化学化工学院,南通226019

出　　处：《精细石油化工进展》2011年第4期32-34,共3页Advances in Fine Petrochemicals

摘　　要：以强碱性阴离子交换树脂为催化剂,乙酰乙酸乙酯、邻氨基苯甲醚为原料合成了邻乙酰乙酰氨基苯甲醚,并考察了反应时间、原料配比、催化剂用量、带水剂及其用量、催化剂重复使用等因素对合成反应的影响。得到了合成邻乙酰乙酰氨基苯甲醚的适宜条件:反应时间4 h,反应温度95～100℃,n(乙酰乙酸乙酯)∶n(邻氨基苯甲醚)=1.4∶1,强碱性阴离子交换树脂的用量1.5 g,带水剂苯的用量20 mL;在此条件下,邻乙酰乙酰氨基苯甲醚的收率可达90.63%,产品纯度≥98.5%。催化剂不经处理可循环使用多次。o - Methoxy acetoacetanilide was synthesized with a strong base anion exchange resin as the catalyst and acetylacetic ester and o - aminophenol methyl ether as the materials, and the effect of reaction time, materials proportioning, catalyst usage, water - carrying agent and its usage as well as the reuse of catalyst on the synthesis reaction was studied. The appropriate conditions of synthetizing o - methoxy acetoacetanilide were identified, i.e. reaction time： 4 h, reaction temperature： 95 - 100℃, n（acetylacetic ester） ： n（o - aminophenol methyl ether） = 1.4 ： 1, strong base anion exchange resin usage： 1.5 g, usage of benzene （the water- carrying agent） ： 20 mL. The yield and purity of o -methoxy acetoacetanilide product can be as high as 90.63% and ≥98.5% at the above -mentioned conditions. In addition, the catalyst can be used repeatedly without being subjected to treatment.

关 键 词：邻乙酰乙酰氨基苯甲醚 邻氨基苯甲醚 乙酰乙酸乙酯 阴离子交换树脂 催化合成 

分 类 号：TQ243.2[化学工程—有机化工]