Thiamine hydrochloride(VB1):An efficient catalyst for one-pot synthesis of α-aminophosphonates under ultrasonic irradiation  

作　　者：Priyanka G.Mandhane Ratnadeep S.Joshi Deepak R.Nagargoje Charansingh H.Gill 

机构地区：[1]Department of Chemistry,Dr.Babasaheb Ambedkar Marathwada University,Aurangabad,Maharashtra 431004,India

出　　处：《Chinese Chemical Letters》2011年第5期563-566,共4页中国化学快报（英文版）

摘　　要：An efficient synthesis of novelα-aminophosphonates by the reaction of aldehydes and amines with triethyl phosphite in the presence of the easily available,inexpensive,and nontoxic catalyst thiamine hydrochloride（VB1）.This method affords theα-aminopho-sphonates under the influence of ultrasound irradiation in aqueous medium,in short reaction times（4-6 min）,high yields（85-95%）, with improved purity.The process is green,mild,inexpensive and excellent yields are the main compensation of this procedure.An efficient synthesis of novelα-aminophosphonates by the reaction of aldehydes and amines with triethyl phosphite in the presence of the easily available,inexpensive,and nontoxic catalyst thiamine hydrochloride（VB1）.This method affords theα-aminopho-sphonates under the influence of ultrasound irradiation in aqueous medium,in short reaction times（4-6 min）,high yields（85-95%）, with improved purity.The process is green,mild,inexpensive and excellent yields are the main compensation of this procedure.

关 键 词：Thiamine hydrochloride（VB1） α-Aminophosphonates Triethyl phosphate WATER Ultrasonication Green synthesis 

分 类 号：O621.3[理学—有机化学]