轻度认知障碍患者血浆同型半胱氨酸和血清维生素B12及叶酸水平变化研究  

The levels of plasma homocysteine, serum vitamin B12 and folate in mild cognitive impairment patients

作　　者：王枫[1] 赵永波[1] 陈维杰[2] 郭春妮[1] 赵圣杰[1] 

机构地区：[1]上海交通大学附属第一人民医院神经科,200080 [2]上海同济大学附属第十人民医院老年科

出　　处：《神经疾病与精神卫生》2011年第2期128-130,共3页Journal of Neuroscience and Mental Health

基　　金：上海市市级医院新兴前沿技术联合攻关项目（SHDC12006108）;上海市科委基础研究重大项目（07DJ14005）;中国博士后科学基金资助项目（20060390635）

摘　　要：目的探讨轻度认知障碍（MCI）患者血浆同型半胱氨酸（Hcy）、血清维生素B12及叶酸水平的变化及相互关系。方法MCI组80例，正常对照组80倒，检测所有观察对象的血浆同型半胱氨酸、血清VitB12及叶酸水平并分析相互关系。结果MCI组血浆Hey水平较正常组显著增高为（18．9±8．8）μmol／L vs（14．3土5．7）μmol／L，而血清叶酸和Vitb2水平在正常组和MCI组之间并没有显著差异；相对于血浆Hcy正常组，MCI比值比（OR）在轻、中度高同型半胱氨酸血症组中增高（OR=1．85，95％CI—1．56～2．95；OR=3．32，95％CI=1．61～6．48；P=0．001）；无论在MCI组还是在正常组中，血浆Hcy与血清叶酸及VitB12的水平均呈负相关。结论血浆Hey水平升高与MCI相关，叶酸和VitB12缺乏可能导致血浆Hey水平升高。Objective To evaluate the levels of plasma homocysteine, Serum vitamin B12 and folate,and investigate the relationship among them. Methods Plasma homocysteine and Serum folate and vitamin B12 were determined in 80 mild cognitive impairment patients and 80 normal elderly subjects as control. Results Mean plasma homocysteine level was higher in MCI patients than in normal ：subjects （18. 9±8.8）μmol/L vs. （14. 3±5.7）μmol/L. However,serum folate and vitamin B12 levels did not dif- fer significantly between normal subjects and those with MCI. The OR for MCI increased in patients with moderate or intermediate hyperhomocysteinemia（ OR = 1.85;95% CI = 1.56--2.95 vs. OR =3. 32;95 % CI = 1.61--6.48; P = 0.001）. Plasma Hcy was negatively correlated with serum folate and vitamin B12 concentrations both in MCI and normal subjects. Conclusions Elevated plasma homocysteine is correlated to higer risk of MCI,the shortage of folate and vitamin l？nz may contribute greatly to hyperhomoeysteinemia.

关 键 词：认知障碍 半腱氨酸 维生素B12 叶酸 

分 类 号：R587.1[医药卫生—内分泌]