中枢类大麻受体拮抗剂利莫那班对2型糖尿病周围神经病变疗效的实验分析  

Experimental analysis on the cure effect of rimonabant, the CB 1 receptor antagonist on rats diabetes peripheral neuropathy

作　　者：赵维元[1] 

机构地区：[1]上海市第六人民医院神经内科,200233

出　　处：《神经疾病与精神卫生》2011年第2期140-143,共4页Journal of Neuroscience and Mental Health

摘　　要：目的观察利莫那班对大鼠糖尿病周围神经病变的疗效，探讨其作用机制。方法采用链尿佐茵素（sTZ）腹腔注射诱导形成糖尿病周围神经病变（DPN）模型，随机分为模型对照组、利莫那班小荆量组、利莫那班大剂量组、正常对照组。糖尿病大鼠造模成功后予利莫那班干预，开始给药24周后将模型组和正常组比较痛阚、坐骨神经传导速度。用酶联免疫吸附测定法（ELISA法）分别测定各组大鼠血清、脊髓及坐骨神经内IL-1β、TNF-α的浓度。结果利莫那班对DNP大鼠痛阈、坐骨神经传导速度（NCV）有明显改善（P〈0．05）。与对照组比较，DPN模型组大鼠的IL-1β、TNF-α的含量显著增高（P〈0．05），利莫那班治疗24周后，与DPN模型组比较IL-1β、TNF-α的含量显著降低（P〈0．05）。结论利莫那班对糖尿病周围神经病变有良好的疗效，可能是通过调节自身免疫功能机制发挥作用。Objective To evaluate the therapeutic effect of rirnonabant,a CB1 receptor antagonist, on diabetic peripheral neuropathy in rats and explore its underlying mechanism. Methods STZ DM model rats were divide into model group,treatment groups I and fl with rimonahant,normal control group. After administering rimonabant 24wks,pain threshold and NCV were compared between model group and normal group. The level of IL-1β and TNF-α in the serum, spinal cord and sciatic nerve were determined respectively by ELISA. Results The concentration of IL-1β and TNF-α dropped noticeably com- pared to DPN group （P 〈0. 05）. Conclusions Rimonabant demonstrated therapeutic effect on rats diabetic peripheral neuropathy,its function may be through adjusting self-immune function.

关 键 词：糖尿病 周围神经系统疾病 神经传导 痛阈 白细胞介素-1 肿瘤坏死因子 利莫那班 

分 类 号：R587.2[医药卫生—内分泌]