抑郁平胶囊抗抑郁作用机理的研究  

Depression capsule mechanism of antidepressant effect

作　　者：张玲 王丽娜 于波[2] 

机构地区：[1]哈药集团世一堂制药厂,哈尔滨150088 [2]哈尔滨市第一医院,哈尔滨150010

出　　处：《哈尔滨商业大学学报（自然科学版）》2011年第2期141-144,154,共5页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：哈尔滨市科技攻关计划项目(2006AA3BS140)

摘　　要：研究抑郁平胶囊抗抑郁的药效学机理.通过抑郁平胶囊对慢性不可预计应激大鼠海马神经元形态学的影响,探讨了抑郁平胶囊抗抑郁的作用机理.从形态学角度证实了慢性应激可导致大鼠海马神经元的损伤,通过运用抑郁平胶囊及阳性对照药百忧解探讨了抗抑郁药的作用机理.抑郁平胶囊可保护和逆转海马神经元的损伤,为其临床治疗抑郁症提供了理论依据.This paper discussed on the depression capsule pharmacodynamic mechanism of antidepressant.The capsule of chronic depression can not be expected to stress the morphology of hippocampal neurons,and to explore the role of depression and antidepressant mechanisms of capsule.This paper confirmed the morphological point of view of chronic stress could lead to damage to hippocampal neurons through the use of depression capsule and the positive control of the antidepressant drug prozac in the mechanism.Depression capsule could protect and reverse the damage of hippocampal neurons,for the clinical treatment of depression provided a theoretical basis.

关 键 词：抑郁平胶囊 慢性不可预计应激大鼠 海马神经元 

分 类 号：R285[医药卫生—中药学]