基于可降解材料构建的腔静脉滤器  

Inferior Vena Cava Filter based on biodegradable materials

作　　者：王小平[1,2] 肖越勇[1] 吴斌[1] 张肖[1] 

机构地区：[1]解放军总医院放射诊断科,北京市100853 [2]景德镇陶瓷学院机电工程学院,江西省景德镇市333403

出　　处：《中国组织工程研究与临床康复》2011年第12期2133-2137,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金资助项目(30970815)~~

摘　　要：背景:永久性腔静脉滤器作为异物长期置于体内可能带来多种并发症,例如滤器移位、腔静脉穿孔、局部血栓形成和腔静脉闭塞等。目的:设计和制作一种可降解的腔静脉滤器。方法:设计了一种带有中心线扩张机构的可降解滤器。采用可降解聚合物左旋聚乳酸制作了带有两侧支和五侧支的可降解滤器模型,用这些滤器模型做力学测试以及体外降解和血栓捕捉实验。结果与结论:实验结果显示中心线不仅能够使滤器扩张,同时也增强了其径向刚度。可降解左旋聚乳酸滤器具有与传统金属滤器相似的力学特性和血栓捕捉能力。可降解滤器存在的主要问题是其在降解过程中会产生碎片。在左旋聚乳酸滤器侧支中复合细线使碎片尺寸减小到约为2mm。尽管这些小的碎片不至于堵塞肺动脉主干或大的分支,但它们对人体的影响目前还不清楚。因此可降解左旋聚乳酸滤器具有潜在的临床应用价值,值得进一步研究。BACKGROUND：Permanent vena cava filter as a long-term foreign body into the body may cause multiple complications,such as filter migration,perforation inferior vena cava（IVC）,local thrombosis,and IVC occlusion,etc.OBJECTIVE：To design and fabricate a biodegradable filter.METHODS：A biodegradable filter was designed with a special center-thread expanding mechanism.Two-strut and five-strut biodegradable filter models were fabricated by using biodegradable polymer Poly（L-Lactide） Acid（PLLA）,on which mechanical tests were performed,and in vitro degradation and clot-trapping experiments were conducted.RESULTS AND CONCLUSION：The experimental results showed the center-thread not only expands the filter,but also enhances its radial stiffness.The biodegradable PLLA filter has similar mechanical property and clot-trapping ability as conventional metal filters.The major problem of the biodegradable filter lies in the debris,which may generate and detach from the filter during the degradation process.By incorporating a thin thread into the PLLA struts,the debris size is reduced to about 2 mm.Although the small debris is not likely to block the trunk or large branches of pulmonary arteries,its impact on human body is still unknown.Therefore,biodegradable filter has the potentials for clinical application and deserves further study.

关 键 词：左旋聚乳酸 可降解腔静脉滤器 肺栓塞 力学性能 血栓捕捉 

分 类 号：R318[医药卫生—生物医学工程]