肌纤维母细胞及在肿瘤间质中激活的纤维母细胞  

Myofibroblasts and activated fibroblasts in tumor stroma

作　　者：衣明 黄荣[2] 张金锋[3] 李书忠[3] 

机构地区：[1]即墨市市北医院,山东省即墨市266211 [2]即墨市第三人民医院,山东省即墨市266211 [3]青岛大学医学院附属医院,山东省青岛市266003

出　　处：《中国组织工程研究与临床康复》2011年第10期1871-1874,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:肌纤维母细胞从1971年被发现以来一直是一个充满争议的课题,近年的研究认识到,该细胞在肿瘤的发生、发展过程中可能起着重要作用。目的:阐述肌纤维母细胞的生物学特征,以及肿瘤间质纤维母细胞在肿瘤的生长、侵袭方面的作用。方法:由第一作者检索万方数据库及Pubmed数据库中1990-01/2010-01与肌纤维母细胞相关的文献,在标题和摘要中以"肌纤维母细胞;肿瘤;转化生长因子;侵袭性"或"myofibroblast;tumor;TGF-β;aggressiveness"为检索词进行检索。选择内容与肌纤维母细胞及肿瘤间质纤维母细胞相关的文章,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到116篇文献,根据纳入标准选择41篇文章进行综述。结果与结论:肌纤维母细胞具有平滑肌和纤维母细胞的特征,肿瘤间质肌纤维母细胞是癌细胞衍生的细胞因子调控成纤维细胞转化而来,通过直接刺激癌细胞的增殖和生存来促进肿瘤生长,并通过水解细胞基质和刺激肿瘤细胞运动来发生侵袭。肌纤维母细胞的出现有助于肿瘤的早期诊断及探索肿瘤治疗的新途径。BACKGROUND：Myofibroblasts has always been a controversial topic since was found in 1971.Recent studies suggest that the cells may play an important role in cancer occurrence and development process.OBJECTIVE：To explore the biological characteristics of myofibroblasts and the role of tumor stromal fibroblasts in tumor growth and invasion.METHODS：Literatures about myofibroblast were retrieved from Wanfang database and Pubmed database（1990-01/2010-01） by the first author.The index words were ＂myofibroblast;tumor;TGF-β;aggressiveness＂ both in English and Chinese,respectively.The articles related to myofibroblasts and tumor stromal fibroblasts were selected,articles in the same field published in recent years or in authorized journals.A total of 116 literatures were primarily selected,and 41 documents of them were involved for summarization according to the inclusion criteria.RESULTS AND CONCLUSION：Myofibroblasts have the characteristics of smooth muscle cells and fibroblast,tumor interstitial myofibroblasts is the regulation of cell-derived cytokines from fibroblasts transformed by directly stimulating the proliferation and survival of cancer cells to promote tumor growth,and by hydrolysis cellular matrix and stimulates tumor cell motility to occur invasion.The emergence of myofibroblasts contributes to the early diagnosis of tumors and to explore new ways of cancer treatment.

关 键 词：肌纤维母细胞 转化生长因子 蛋白水解酶 肿瘤 侵袭性 

分 类 号：R318[医药卫生—生物医学工程]