补肾中药对超排卵周期子宫内膜容受性影响的超声学评价  

Effect of Chinese Kidney Medicine on Ultrasound Parameters during Super Ovulation

作　　者：孙振高[1] 连方[1] 李婷婷[1] 张建伟[1] 张宁[1] 郭颖[1] 王瑞霞[1] 

机构地区：[1]山东中医药大学附属医院生殖中心,济南市250011

出　　处：《中国超声医学杂志》2011年第4期353-356,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然基金委基金项目(No.30901920);山东省自然基金资助项目(No.Q2008C17);山东省中医药科技发展计划项目(No.2009-038)

摘　　要：目的通过超声检查,评价补肾中药改善超排卵过程子宫内膜容受性的临床价值。方法将64例进人体外受精胚胎移植(IVF-ET)治疗周期的不孕患者随机分为两组,选用控制性超排卵方案,分别用二至天癸颗粒联合促性腺激素(治疗组,31例)和单用促性腺激素(对照组,33例)治疗,对两组患者子宫内膜厚度及分型、子宫动脉搏动指数和阻力指数、子宫内膜血流、优质卵率、受精率、优质胚胎率、移植胚胎数及临床妊娠率进行评定。结果治疗组与对照组人绒毛膜促性腺激素(HCG)注射日子宫内膜厚度比较。差异无统计学意义(P>0.05);两组HCG注射日子宫内膜分型、内膜及内膜下血流、子宫动脉搏动指数和阻力指数比较,差异有统汁学意义(P<0.05);两组优质卵率、受精率、优质胚胎率、移植胚胎数比较,差异无统计学意义(P>0.05);两组临床妊娠率比较,差异有统计学意义(P<0.05)。结论在IVF-ET过程中联合应用补肾中药,可以提高子宫内膜容受性,进而提高临床妊娠率。Objective To evaluate the effect of Chinese Kidney medicine on ultrasound parameters of endometrium during super ovulation process. Methods 61 infertiI women undergoing in vitro fertilization and embryo transfer （IVF-ET）were randomized into test group,treated with Erzhi Tiangui Granules（ ETG）and gonadotropin（Gn）（ 31 cases） .and control group, treated with Gn only（33 cases）, to evaluate the syndrome points of Traditional Chinese Medicine（TCM）, the dose and days of Gn, thickness and type of endometrium, pulsatility index（PI）and resistent index（RI） of uterous artery,endometria[ blood stream, hormone level in serum,high-quality oocyte rate, fertility rate,high-quality embryo rate,imphmted embryo rate and the clinical pregnancy rate of both. Results There was statistical significance before and after the treatment in the syndrome points of Kidney-deficiency（P〈0.05）,type of endometrium,PI and RI of uterous artery,endometrial and under endometrial blood stream on HCG day（P〈0.05） ,and in the clinical pregnancy rate（P〈0.05）of two groups, while not in the thickness of endometrium,dose and days of Gn,hormone level on HCG day, high-quality oocyte rate, fertility rate. high-quality embryo rate and implanted embryo rate （P〉 0.05 ）. Conclusions In the process of IVF-ET with kidney medicine,through amelioration of the ultrasonic parameters,the endometrial receptivity can be improved,and then the clinical pregnancy rate can be increased.

关 键 词：补肾中药 超排卵周期 子宫内膜 超声参数 

分 类 号：R271.9[医药卫生—中西医结合] R445.1[医药卫生—中医妇科学]