围着床期和HCG日子宫内膜3DU-PDA参数评价子宫内膜容受性  

Assessment of Endometrial Receptivity by Three-dimensional Ultrasonography and Power Doppler Angiography during Peri-implantation Period and HCG Administration Day

作　　者：李秋华[1] 余敏[1] 陈雷宁[1] 李红[1] 罗琛[1] 陈思梅[1] 全松[1] 

机构地区：[1]南方医科大学南方医院妇产科生殖医学中心,广州市510515

出　　处：《中国超声医学杂志》2011年第4期360-363,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金(No.30872769);南方医院新技术新项目基金(No.20060002)

摘　　要：目的探讨IVF前一自然周期围着床期及绒毛膜促性腺激素注射日(HCG日)子宫内膜三维超声能量多普勒血管成像(three-dimensional ultrasonography and power Doppler angiography,3DU-PDA)参数评价子宫内膜容受性并预测体外受精胚胎移植(IVF-ET)结局的价值。方法选择南方医院生殖医学中心2009年4月至2009年12月行IVF-ET治疗的67例妇女为研究对象,追踪助孕结局分为临床妊娠组(31例)和未妊娠组(36例)。比较两组一般情况、临床资料和围着床期及HCG日子宫内膜3DU-PDA参数。结果临床妊娠组和未妊娠组之间围着床期子宫内膜3DU～PDA参数没有显著性差异(P均>0.05)。临床妊娠组HCG日子宫内膜下FI高于未妊娠组,差异有统计学意义(t=2.398,P=0.019),但预测妊娠的ROC曲线下面积仅为0.475。结论在辅助生殖技术中测量HCG日子宫内膜3DU-PDA参数有利于评价子宫内膜容受性,但是特异性不高。Objective To evaluate the role of endometrial parameters by 3DU PDA during peri-implantation period and HCG administration day in the prediction of endometrial receptivity. Methods 67 patients undergoing IVF/ ICSI-ET treatment from 1st April 2009 to 31st December 2009 were analyzed retrospectively. Endometriat tissue was obtained by disposable suction tubes from uterine cavity after 7 days of ovulation. Endometrial tissue was used to Scanning electron microscope observation pinopods. All subjects were divided into two groups according to their IVF- ET outcome： clinical pregnancy（31 cases） ; nonpregnant group （36 cases）. Data analysis was carried out on the patients＇characteristics, clinical information and 3DU-PDA parameters. Results The subendometrial FI on HCG day for the clinical pregnancy group was significantly higher than that of the nonpregnant group （P=0. 019）. The ROC curve analysis showed that subendometrial FI on the HCG day had the area under the eurve〈0.5（0. 475）. Conclusions In the IVF/ICSI-ET cycles , 3DU-PDA parameters on HCG day is helpful to assess endometrial receptivity,but the Specificity is low.

关 键 词：三维超声能量多普勒血管成像 体外受精-胚胎移植 血管指数 血流指数 血管血流指数 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.8[医药卫生—诊断学]