弱激光促进糖尿病大鼠模型皮肤创伤愈合的实验研究  

Study of Low-Level Laser Therapy Facilitates Cutaneous Wound Healing in Diabetic Rats

作　　者：马慧[1] 李迎新 崔欲晓[1] 陈洪丽[1] 康美玲[1] 董晓曦[1] 

机构地区：[1]天津医科大学生物医学工程学院,天津300070 [2]中国医学科学院生物医学工程研究所激光医学实验室,天津300192

出　　处：《应用激光》2011年第2期185-187,共3页Applied Laser

摘　　要：探讨弱激光对糖尿病大鼠皮肤创伤愈合过程的影响。32只糖尿病大鼠背部皮肤全层创口随机分为4组,分别为:功率密度5、10和15mW/cm^2的630nm半导体激光照射组及空白对照组。弱激光照射能明显加速创面收缩,减轻炎症反应,加快成纤维细胞的增殖和胶原蛋白的合成,促进上皮细胞和毛细血管再生,促进创伤愈合。其中功率密度15mW/cm^2的弱激光治疗组疗效最为明显。实验前后各组大鼠血糖水平均无显著差异。弱激光对糖尿病大鼠皮肤创伤愈合确实存在促进作用,且疗效存在光学参数依赖性。To investigate the effect of low-level laser therapy on healing of cutaneous excisional wounds in diabetic rats. The dorsal cutaneous exeisional wounds of 32 diabetic rats were divided randomly into 4 groups. Three groups were irradiated with a 630 nm semiconductor laser each with respective three power densities of 5,10 and 15 mW/cm^2, whereas the fourth group served as a eontroh Low-level laser irradiation can obviously accelerate wound contraction,reduce inflammatory reaction significantly, speed fibroblasts proliferation and collagen synthesis, promote epithelial cells and capillaries regeneration, promote wound healing.Effect of low-level laser therapy with 15 mW/cm^2 is most obvious. Before and after the experiment blood glucose levels of all groups were no significant difference. It can be concluded that low-level laser therapy have bene？cial effects on wound healing in diabetic： rats,and the outcomes have a relationship with optical parameters.

关 键 词：弱激光 功率密度 糖尿病大鼠 皮肤创伤愈合 

分 类 号：R318.51[医药卫生—生物医学工程]