孕激素在红斑狼疮发病中的免疫调节作用  

Immunomodulatory activities of progesterone in the development of systemic lupus erythematosus

作　　者：方险峰[1] 李家文[2] 

机构地区：[1]广西中医学院附属瑞康医院皮肤科,南宁530011 [2]华中科技大学同济医学院附属协和医院皮肤科

出　　处：《国际皮肤性病学杂志》2011年第3期146-148,共3页International Journal of Dermatology and Venereology

摘　　要：孕激素效应由孕激素核受体或膜受体介导。研究证实，淋巴细胞、自然杀伤细胞，单核细胞等多种免疫细胞表达孕激素核受体或膜受体。孕激素可直接通过孕激素受体或间接通过孕激素诱导的封闭因子发挥免疫调节效应，诱导Th2细胞反应、抑制Th1细胞反应，增加B淋巴细胞不对称抗体合成，抑制自然杀伤细胞、单核细胞的杀伤活性。孕激素血清水平下降、孕激素受体表达调节障碍，导致其免疫调节作用降低，参与系统性红斑狼疮发病及病情进展。The effects of progesterone are mediated by its nuclear or membrane receptors, which have been identified in a variety of immune cells including lymphoeytes, natural killer cells, monocytes, etc. Recently, a growing body of evidence has confirmed the immunomodulatory activities of progesterone, including induction of T helper 2 （Th2） cell response, inhibition of Thl cell reaction, promotion of asymmetric antibody synthesis by B cells, suppression of killing activity of natural killer cells and monocytes, which are mediated directly by its receptors or indirectly by progesterone-induced blocking factors. Lower level of progesterone in sera and impaired progesterone receptor expression have been identified in systemic lupus erythematosus, which may result in an attenuation in the immunomodulatory effect of progesterone, and contribute to the initiation and progression of systemic lupus erythematosus.

关 键 词：红斑狼疮 系统性 孕激素类 神经免疫调节 

分 类 号：R593.241[医药卫生—内科学]