电子线治疗大鼠继发性泡球蚴病的实验研究  

Effect of 6 MeV Radiotherapy on Secondary Echinococcus multilocularis Infection in Rats

作　　者：包永星[1] 张月芬[1] 倪雅琼[1] 谢增如[1] 齐洪志[1] 毛睿[1] 杨玉刚[1] 温浩[1] 

机构地区：[1]新疆医科大学第一附属医院肿瘤中心,乌鲁木齐830054

出　　处：《中国寄生虫学与寄生虫病杂志》2011年第2期127-129,共3页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金(No.81060150);新疆维吾尔自治区包虫病重点实验室开放课题项目(No.XJDX0202-2005-01)~~

摘　　要：目的探讨电子线治疗大鼠继发性泡球蚴病的疗效。方法雌性SD大鼠继发性泡球蚴病动物模型随机分为实验组和对照组,每组5只,实验组给予6-MeV线照射,剂量为20 Gy,共照射2次,每次间隔7 d,对照组不照射。放疗结束后30 d观察各组泡球蚴囊的病理变化。结果实验组泡球蚴呈不同程度的改变和破坏,结构异常,角质层、生发层普遍变性肿胀或分离脱落,育囊和原头节少见;对照组泡球蚴结构基本正常,角质层、生发层清晰,育囊内有数量不等的原头节。结论电子线有抑制泡球蚴生长的作用。Objective To explore the effect of 6-MeV X-ray radiotherapy on secondary Echinococcus multilocu-laris infection in rats.Methods Female SD rats were used to develop a secondary infection model,and then randomly divided into experimental group and control group（5/group）.Rats in experimental group received two irradiations at 7-day intervals with the same dose（20 Gy） which applied with 6-MeV ray.The rats in control group did not receive any treatment.At one month after the second irradiation,the pathomorphological changes of E.multilocularis cysts were observed.Results Cysts in experimental group showed different degrees of damage,including that the laminated layer and germinal layer became swollen and separated from each other,brood capsules and protoscoleces were rare.The structure of cysts was normal in control group,laminated layer and germinal layer were clear,and there were many protoscoleces in the brood capsule.Conclusion 6 MeV radiotherapy can inhibit the growth of E.multilocularis.

关 键 词：泡球蚴病 多房棘球绦虫 放射治疗 大鼠 

分 类 号：R532.32[医药卫生—内科学]