舌下粉尘螨滴剂治疗儿童支气管哮喘伴变应性鼻炎的有效性和安全性  

Clinical efficacy and safety of sublingual immunotherapy using standardized dermatophagoides farinae extract for children with combined allergic rhinitis and asthma syndrome

作　　者：温赤君[1] 朱明风[2] 任文美[1] 刘笑迎[1] 钱红[2] 

机构地区：[1]上海市第二人民医院儿科,200011 [2]上海市第二人民医院核医学科,200011

出　　处：《中华耳鼻咽喉头颈外科杂志》2011年第5期393-396,共4页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

摘　　要：目的探讨舌下含服标准化粉尘螨变应原疫苗治疗儿童支气管哮喘伴变应性鼻炎的有效性和安全性。方法采用前后自身对照，比较52例年龄4～14岁粉尘螨过敏的支气管哮喘伴变应性鼻炎患儿治疗前及免疫治疗1年、2年后的症状评分、药物评分以及不良反应发生率，评价其疗效和安全性。以SPSS17．0软件对数据进行统计学分析。结果治疗前患儿支气管哮喘日间、夜间的症状评分分别为（3．22±0．66）、（2．05±0．57）分，治疗后1年分别为（1．68±0．61）、（0．94±0．32）分，治疗后2年分别为（0．61±0．28）、（0．43±0．13）分，治疗后1年较治疗前明显降低，治疗后2年较治疗后1年明显降低，差异均有统计学意义（q值分别为15．25、13．78、10．29、6．07，P值均〈0．01）。治疗前患儿变应性鼻炎的症状评分及药物评分分别为（2．34±0．59）、（3．09±1．01）分，治疗后1年分别为（1．21±0．46）、（1．89±0．64）分，差异有统计学意义（q值分别为15．48、18．61，P值均〈0．01）；治疗后2年分别为（1．02±0．37）、（1．49±0．38）分，与治疗后1年相比差异无统计学意义（q值分别为2．53、2．78，P值均〉0．05）。治疗过程中未发生严重不良事件，仅表现为口腔不适感。结论标准化粉尘螨变应原疫苗舌下含服是一种治疗儿童粉尘螨支气管哮喘伴变应性鼻炎的安全有效方法。Objective To study the clinical efficacy of sublingual immunotherapy using standardized dermatophagoides farinae extract for children with combined allergic rhinitis and asthma syndrome. Methods Fifty-two children, from 4 to 14 years of age, with mite-sensitive combined allergic rhlnitis and asthma syndrome were treated sublingually with standardized dermatophagoides farinae extrac, t. The clinical efficacy was evaluated by monthly follow-up visits. After treatment for 1 or 2 years using the standardized dermatophagoides farinae extract, the asthma and rhinitis symptom scores, medication scores and adverse reactions before and after treatment were evaluated. SPSS 17.0 software was used to analyze the data. Results The allergic asthma symptom scores before treatment during the day were 3.22 ± 0.66 and at night 2.05±0.57. After 1 year of treatment, the day and night scores （1.68 ± 0.61, 0.94 ± 0.32） respectively, were decreased significantly （q values were 15.25 and 13.78 respectively, all P 〈 0.01 ）. After 2 years of treatment, the scores （0.61 ±0.28, 0.43 ± 0.13 ） were also decreased significantly （q values were 10. 29 and 6. 07 respectively, all P 〈 0. 01 ）. The allergic rhinitis symptom scores and medication scores were 2.34 ± 0.59 and 3.09 ± 1.01 respectively before treatment and 1.21 ± 0.46 and 1.89 ±0.64 after 1 year of treatment. The differences were significant（q values were 15.48 and 18.61 respectively, all P 〈0. 01 ）. The allergic rhinitis symptom scores and medication scores were 1.02 ± 0. 37 and 1.49 ± 0.38 after 2 years of treatment. There was no significant difference between 2 years of treatment and 1 year of treatment（q values were 2.53 and 2.78 respectively, all P 〉0.05）. There were no severe adverse events during the treatment, except for mild mouth cavity discomfort. Conclusions Sublingual immunotherapy using standardized dermatophagoides farinae extract is safe and effective in the treatment of children with combined allergic rhinitis and asthma syndr

关 键 词：哮喘 鼻炎 变应性 常年性 粉尘螨 脱敏法 免疫 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]