丙种球蛋白联合匹多莫德预防小儿哮喘复发前瞻性研究  

A Prospective Study on Preventing Recurrence of Bronchial Asthma in Children by Combining Intravenous Drip γ-Globulin with Oral Pidotimod

作　　者：蔡幸生[1] 朱勇斌[1] 林丽爱 张淳[1] 余华斐[1] 林霞[1] 林旭忠[1] 

机构地区：[1]广东省揭阳市人民医院儿科,522000 [2]广东省揭阳市榕城区妇幼保健院,522000

出　　处：《中华全科医学》2011年第6期843-844,共2页Chinese Journal of General Practice

基　　金：2001年度广东省揭阳市卫生局医学科研项目(2001002)

摘　　要：目的探讨定期静滴丙种球蛋白联合口服匹多莫德防止小儿支气管哮喘复发及再次住院治疗效果。方法将50例支气管哮喘急性发作期经住院治疗控制后出院的患儿被随机分成对照组23例,观察组27例。对照组按中华医学会儿科学分会呼吸学组制定的儿童哮喘防治常规继续抗哮喘治疗,并定期评估,及时进行降级与升级治疗。观察组在对照组治疗的基础上,定期静滴丙种球蛋白和口服匹多莫德口服液治疗。每年于季节转换时(1月、4月、7月、10月)各静滴丙种球蛋白1次,2.5 g/次,同时服用匹多莫德口服液,1次/d,1支/次(0.4 g),每个疗程1个月。每2个月随访1次,随访2年。比较两组患儿哮喘复发率、复发次数、再次住院率等。结果对照组复发15例,复发率65.22%,观察组复发6例,复发率22.22%(P<0.01)。对照组哮喘发作次数为(4.67±2.13)次,观察组(2.33±1.03)次(P<0.05)。对照组再次住院14例,再次住院率60.87%,观察组再次住院3例,再次住院率11.11%(P<0.01)。结论定期静滴丙种球蛋白联合口服匹多莫德能显著减少小儿支气管哮喘复发率及再次住院率,减少复发次数,且未见明显副作用,值得推广应用。Objective To investigate the effects of intravenous drip γ-globulin combined with oral Pidotimod on preventing the recurrence and readmission bronchial asthma in children.Methods A total of 50 children with bronchial asthma were randomly divided into observation（27 cases） and control（23 cases） groups.The control group was treated to continue anti-asthma according to routine of prevention and treatment children with asthma,which was formulated by cooperation group of prevention and treatment children with asthma in our country.The observation group was treated by intravenous drip γ-globulin（2.5 g every time,four times a year,in January,April,July,October）,meanwhile oral Pidotimod（0.4 g once a day,each course of treatment was 1 month） based on the treatment of the control group.The patients were followed up once every 2 months.The time of follow-up was 2 years.The recurrent rate of asthma,the mean recurrent times of asthma,the rate of readmission were compared in both groups.Results The recurrent rates of asthma in control and observation groups were 65.22% and 22.22%,respectively（P0.01）.The mean recurrent times in control and observational groups were 4.67±2.13 and 2.33±1.03,respectively（P0.05）.The rates of readmission in control and observational groups were 60.87% and 11.11%,respectively（P0.01）.Conclusion The rates of recurrence and readmission of asthma were significant decreased,the mean recurrent times were decreased by combining intravenous drip γ-globulin with oral Pidotimod in periodic.There are no obvious side effects.

关 键 词：丙种球蛋白 匹多莫德 哮喘 复发 预防 儿童 

分 类 号：R562.25[医药卫生—呼吸系统]