复方决明子冲剂对大鼠血脂调节的研究  

Study of compound electuary of Cassia tora for regulating blood lipids in rats

作　　者：赵振铭[1] 张丽[1] 王义和[2] 谢皖[3] 

机构地区：[1]武警医学院药学系,天津300162 [2]武警医学院生理教研室 [3]天津华立达生物工程有限公司

出　　处：《武警医学》1999年第8期435-437,共3页Medical Journal of the Chinese People's Armed Police Force

基　　金：国家科委火炬计划项目

摘　　要：目的　为临床治疗高血脂症提供新型中药制剂。方法　将４０ 只 Ｗｉｓｔａｒ 雄性大鼠根据大鼠的体重分为对照组、低剂量组、中剂量组和高剂量组，每组１０ 只，分别于实验后第１４ 天及第２８ 天对低、中、高剂量组血清总胆固醇（ Ｔ Ｃ） 、血清甘油三酯（ Ｔ Ｇ） 、血清高密度脂蛋白 Ｃ（ Ｈ Ｄ Ｌ－ Ｃ） 、 Ｈ Ｄ Ｌ－ Ｃ／ Ｔ Ｃ 比值、动脉硬化指数（ Ａ Ｉ） 进行测定。结果　与饲以高脂饲料的阳性对照组大鼠相比，实验第１４ 天及第２８ 天时各实验组大鼠血清 Ｔ Ｃ 含量显著低于对照组（ Ｐ ＜ ００５） 。 Ｈ Ｄ Ｌ－ Ｃ／ Ｔ Ｃ 比值，第１４ 天时低、中、高剂量组和第２８ 天时中、高剂量组均显著高于对照组（ Ｐ ＜ ００５） 。 Ａ Ｉ比值在第１４天时高剂量组和第２８ 天时中、高剂量组均低于对照组（ Ｐ ＜ ００５） 。本实验未见受试物对 Ｔ Ｇ 有影响。结论　认为新中药组方———复方决明子冲剂具有调节血脂的作用。Objective To provide novel preparation of traditional Chinese Medicine for clinical treatment of hyperlipemia.Methods According to body weight,forty male wistar rats were divided into 4 groups,each consisting of 10 rats:control group (CG),lower dosage group (LD),moderate dosage group (MD) and higher dosage group (HD).Serum (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C),HDL-C/TC and atherosclerotic index (AI) of LD,MD and HD were determined at days 14 and 28.Results Compared with positive CG rats fed with 28 high fat food,serum TC of experimental group in the 14 and 28 days was significantly lower than that of CG(P<0 05).HDL-C/TC of the LD,MD,HD at the 14th day and MD,HD at the 28 day was significantly higher than that of CG(P<0 05).AI of the HD at the 14th day and MD at the 28th day was all significantly lower than that of CG(P<0.05).No effect on serum TG the arug had.Conclutions Compound electuary of cassia tora possesses the action of regulating blood lipids.

关 键 词：复方决子冲剂 大鼠 血脂 调节 中药 药理 

分 类 号：R286.26[医药卫生—中药学]