程氏分清饮对大鼠肾病综合征的作用  

Experimental Study on Effects of Cheng's Fenqingyin on Rats with Nephritic Syndrome

作　　者：孟冬月[1] 申社林[1] 程根群 李妤蓉[2] 王锦[1] 李永刚[1] 崔彦岭[1] 

机构地区：[1]邢台医学高等专科学校,河北邢台054000 [2]邢台医学高等专科学校第二附属医院,河北邢台054000

出　　处：《中国实验方剂学杂志》2011年第10期183-186,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河北省科技支撑计划项目(20071122003)

摘　　要：目的:探讨程氏分清饮对大鼠肾病综合征的治疗作用。方法:选取雄性SD大鼠50只,随机分为正常对照组(A)、模型对照组(B)、程氏分清饮治疗组(C组)、激素治疗组(D组)、程氏分清饮加激素治疗组(E组)。采用一次性尾静脉注射阿霉素(5.5 mg·kg-1)的方法建立大鼠肾病综合征模型。观察程氏分清饮对肾病大鼠尿蛋白、血清白蛋白(Alb)、尿素氮(BUN)、血清肌酐(Cr)、甘油三酯(TG)及肾脏组织病理形态学的影响。结果:各治疗组24 h尿蛋白明显低于B组(P<0.05,P<0.01);各治疗组血清生化指标较B组明显改善(P<0.05);肾组织病理改变明显。结论:程氏分清饮可以明显改善肾病大鼠的尿蛋白及脂质代谢异常,保护肾功能,减轻肾损害,对大鼠肾病综合征具有良好的治疗作用。Objective：To study the effects of Cheng＇s Fenqingyin on the rats with nephritic syndrome.Method：Fifty male SD rats were randomLy divided into five groups（ten for each group）：the normal control group（A）,model control group（B）,Cheng＇s Fenqingyin group（C）,hormone group（D） and Cheng＇s Fenqingyin ＋hormone group（E）.Rats model with nephritic syndrome was established by one-time caudal vein injection of Adriamycin（5.5 mg·kg-1）.The effects of the Cheng＇s Fenqingyin on the rats with nephritic syndrome were observed in the urine protein,serum albumin（Alb）,blood urea nitrogen（BUN）,serum creatinine（Cr）,serum triglyceride（TG） and pathological kindney.Result：The 24 h urine protein in the treatment groups was significantly lower than in group B（P0.05,P0.01）.Serum biochemical indicators in each treatment group significantly improved in contrast to group B.The kindney significantly changed.Conclusion：Cheng＇s Fenqingyin can effectively improve the urine protein and lipid metabolism of the nephritic rats,protect the renal function and reduce the renal injury,so Cheng＇s Fenqingyin is proved to have remedial effect for Rats with nephritic syndrome.

关 键 词：程氏分清饮 大鼠 肾病综合征 

分 类 号：R285.5[医药卫生—中药学]