性激素结合球蛋白在妊娠期糖尿病胎盘组织中的变化及其意义  

Expression Changes of Sex Hormone Binding Globulin in GDM Placental Tissue and Its Significance

作　　者：金镇[1] 孙磊[1] 滕卫平 张亚南[1] 艾婉婷[1] 王娉婷[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,沈阳110004 [2]辽宁省内分泌疾病重点实验室,沈阳110001

出　　处：《中国医科大学学报》2011年第5期446-448,共3页Journal of China Medical University

基　　金：辽宁省自然科学基金项目(20042089);辽宁省教育厅高校科研计划(20062013)

摘　　要：目的探讨性激素结合球蛋白(SHBG)在妊娠期糖尿病(GDM)胎盘组织中的表达变化及其意义。方法应用RT-PCR、Western blot及ELISA法分别检测GDM胎盘组织中SHBG mRNA、SHBG蛋白及SHBG浓度。结果 GDM组与对照组比较:SHBG mRNA(1.839±0.827 vs 2.485±1.950)、SHBG蛋白(1.852±0.645 vs 2.522±0.842)及SHBG浓度(2.071±0.417 vs 2.495±0.529)都显著降低,有统计学差异(P<0.05)。结论 GDM时胎盘滋养细胞存在着SHBG,但其合成和分泌减少,在GDM发病过程中发挥重要作用。Objective To explore expression changes of sex hormone binding globulin in GDM placental tissue and its significance.Methods Detecting SHBG mRNA,SHBG protein and SHBG concentration in GDM placental tissue respectively used RT-PCR,the Western blot and ELISA.Results GDM group compared with controls：SHBG mRNA（1.839±0.827 vs 2.485±1.950）,SHBG protein（1.852±0.645 vs 2.522±0.842）and SHBG concentration（2.071±0.417 vs 2.495±0.529） were significantly reduced（P〈0.05）.Conclusion SHBG exist in GDM placental nourish cells but its synthesis and secretion were reduced.This played an important role in the pathogenesis of GDM.

关 键 词：性激素结合球蛋白 妊娠期糖尿病 胎盘 

分 类 号：R714.25[医药卫生—妇产科学]