多潜能干细胞的研究进展  

Research status of pluripotent stem cells from different origins

作　　者：王书军[1] 张文杰[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院整形外科,组织工程国家工程中心,200011

出　　处：《国际生物医学工程杂志》2011年第2期122-125,共4页International Journal of Biomedical Engineering

摘　　要：多潜能干细胞是一类具有向外胚层、中胚层以及内胚层细胞分化的干细胞，从胚胎发育早期分离获得的胚胎干细胞、胚胎生殖细胞到成体组织骨髓、睾丸中获得的干细胞。都具有三胚层分化能力。近年来，研究证实，可以将成体分化细胞经基因操作逆转为多能干细胞。就各种来源多潜能干细胞的特点予以综述，并对细胞间可能存在的关系加以探讨。Pluripotent stem cells are type of cells that can differentiate into cells of ectoderm, mesoderm and endoderm layers. Cells isolated from developing embryos sueh as embryonic stem cells, embryonic germ cells, as well as cells derived from adult tissues and bone marrow and testis, have been proved to be pluripotent. Recent studies demonstrated that differentiated cells from adult could be reprogrammed to become pluripotent by genetic manipulation. The eharacteristics of pluripotent cells from different origins are summarized in this review, and the possible relationship between those populations is discussed.

关 键 词：多潜能干细胞 胚胎干细胞 胚胎生殖干细胞 诱导性多能干细胞 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]