呋塞米联合多巴胺持续静脉泵入治疗利尿剂抵抗性心力衰竭52例临床分析  

Clinical analysis of Furosemide and Dopamine continued vein pumping in treatment of 52 cases with diuretic-resistant heart failure

作　　者：刘建[1] 贾静涛[1] 

机构地区：[1]河南省南阳市第九人民医院,河南南阳473000

出　　处：《中国医药导报》2011年第15期83-84,共2页China Medical Herald

摘　　要：目的:探讨持续静脉泵入呋塞米(速尿)和多巴胺对顽固性心衰的疗效是否优于单纯泵入呋塞米。方法:将52例利尿剂抵抗性心力衰竭患者随机分为两组,对照组26例采用常规抗心力衰竭治疗基础上,单纯持续静脉泵入速尿。治疗组26例在常规抗心力衰竭治疗的基础上采用联合呋塞米和多巴胺持续静脉泵入。连续应用3 d,观察治疗前后两组在临床症状、体征及心功能指标等方面的变化。结果:治疗组临床总有效率为88.5%(23/26),对照组为57.7%(15/26),两组比较差异有统计学意义(P<0.05))。治疗组治疗前后左室射血分数[(28.2±3.2)vs(41.0±15.1)]、左室舒张末内径[(64.2±5.1)vs(53.1±4.8)]比较,差异均有统计学意义(均P<0.05);与对照组治疗后左室射血分数[(41.0±15.1)vs(33.1±4.3)]、左室舒张末内径[(53.1±4.8)vs(60.1±5.8)]比较,差异均有统计学意义(均P<0.05)。结论:在常规抗心力衰竭治疗的基础上采用持续静脉泵入多巴胺和速尿,对袢利尿剂抵抗性心力衰竭患者疗效显著,值得临床推广应用。Objective：To explore the efficacy of Furosemide and Dopamine continued vein pumping in treatment of refractoriness heart failure compared with the Furosemide.Methods：52 patients were divided into treatment group and control group,each 26 cases.The control group was used Furosemide,the treatment group was used the Furosemide and Dopamine continued vein pumping treatment,used 3 days.Symptom,sign,the index of heart funditon were analyzed before and after treatment in two groups.Results：The total effective rate in the control group was 57.7%（15/26） and the treatment group was 82.3%（23/26）,there was a significant difference（P0.05）.Before and after treatment in the treatment group,LVEF [（88.5±3.2） vs（41.0±15.1）] and LVEDD [（64.2±5.1） vs（53.1±4.8）],there was a significant difference（P0.05）.LVEF[（41.0±15.1） vs（33.1±4.3）] and LVEDD [（53.1±4.8） vs（60.1±5.8）] after treatment in the two groups,there was a significant difference（P0.05）.Conclusion：Based on the conventional methods Furosemide and Dopamine continued vein pumping in treatment of refractoriness heart failure is effective,it is worthy of application.

关 键 词：多巴胺 呋塞米 利尿剂抵抗 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]