对氟苯酚的合成工艺研究  

A Practical Synthesis Route of p Fluorophenol

作　　者：刘加庚[1,2] 孙维林[1,2] 徐端均[1,2] 徐元植 

机构地区：[1]浙江大学化学系 [2]浙江大学高分子系

出　　处：《精细化工》1999年第4期43-46,共4页Fine Chemicals

摘　　要：以对氟苯胺为原料制备了对氟苯酚。在稀硫酸溶液中进行重氮化反应制得重氮盐后，采用反应蒸馏的工艺技术，将得到的重氮盐溶液滴加到沸腾的酸性介质中水解，在进行水解的同时将产物对氟苯酚蒸馏使其离开反应体系，从而大大提高了产物收率。当水解介质的硫酸与水为等体积比，水解温度为１３０℃左右时，可得到８０％以上的摩尔收率，且产物的纯度可达９０％以上。p Fluorophenol is synthesized from WTBXp fluoroaniline through diazotization method. p Fluoroaniline is at first diazotized in dilute sulfuric acid, and then the solution of diazonium sulfate is droped into boiling sulfuric acid solution, hydrolyzed and at the same time, the product is distilled out of the reaction system. Because the reactiondistilling method decreases the opportunity for the product to react with diazonium salt, the yield rises to above 80% when the diazonium sulfate is hydrolyzed at 130 in a medium consisting of 11 sulfuric acid and water (vol.).

关 键 词：对氟苯酚 重氮化反应 反应蒸馏 合成 工艺 

分 类 号：TQ243.3[化学工程—有机化工]