男性心房颤动类型对血浆脑钠肽水平的影响  

Influence of atrial fibrillation type on plasma brain natriuretic peptide level in male patients

作　　者：于立成[1] 刘庚[1] 姚靖[1] 

机构地区：[1]北京市海淀医院心内科,100080

出　　处：《中国综合临床》2011年第5期464-466,共3页Clinical Medicine of China

摘　　要：目的探讨各类型男性心房颤动与血浆脑钠肽含量的关系。方法选择人院男性心房颤动患者58例，其中阵发性心房颤动35例（阵发性心房颤动组），持续性心房颤动14例（持续性心房颤动组），永久性心房颤动9例（永久性心房颤动组），于入院后24h内完成超声心动图和（或）心电图检查，清晨安静平卧状态留取静脉血，采用放射免疫法检测脑钠肽含量。结果男性永久性心房颤动组血浆脑钠肽平均水平[（2343．25±820．24）μg／L）]显著高于持续性心房颤动组[（576．43±223．07）μg／L]及阵发性心房颤动组[（632．74±103．93）μg/L]，差异有统计学意义（t值分别为8．74，8．73，P均〈0．001），持续性心房颤动组与阵发性心房颤动组血浆脑钠肽水平差异无统计学意义（t值为0．59，p〉0．05）。结论脑钠肽不仅是反映早期心功能受损的敏感指标，而且与心房颤动有较密切的关系，尤其在永久性心房颤动患者明显升高。Objective To explore the effect of different type of atrial fibrillation（AF） on plasma brain natriuretic peptide（BNP） level in male patients. Methods Fifty-eight hospitalized male patients with AF were enrolled,including 35 cases with paroxy.smal AF, 14 cases with persistent AF, and 9 cases with permanent AF. All subjects had the examination of echocardiography/electrocardiogram within 24 h after admission. Venous blood sample were collected in a quiet prostration state on the next early morning for BNP detection. The plasma BNP level was determined by radioimmunolagy-assay（RIA）. Results The average level of plasma BNP in male patients with permanent AF（2343.25± 820. 24） μg/L was significantly higher than those with persistent AF （ [ 576. 43 ± 223.07 ] μg/L, t = 8.74, P 〈 0. 001 ） and paroxysmal AF （ [ 632.74 ± 103.93 ] μg/L, t = 8. 73, P 〈 0. 001 ）, but there was no significant difference between the last two groups （ t = 0. 59, P 〉 0. 05 ）. Conclusion BNP is a sensitive indicator of early heart function impairment related with AF, particularly elevates in male patients with permanent AF.

关 键 词：心房颤动 脑钠肽 心律失常 

分 类 号：R541.75[医药卫生—心血管疾病]