血清基质金属蛋白酶-9与2型糖尿病颈动脉粥样硬化的关系  

Relationship between serum matrix metalloproteinase-9 and carotid atherosclerosis in type 2 Diabetes

作　　者：鞠巍[1] 赵晓娟[2] 

机构地区：[1]沈阳医学院沈洲医院内分泌科,110002 [2]中国医科大学第一附属医院内分泌科

出　　处：《中国综合临床》2011年第5期499-501,共3页Clinical Medicine of China

摘　　要：目的探讨血清基质金属蛋白酶_9（MMP-9）与2型糖尿病（T2DM）患者颈动脉粥样硬化的关系。方法选择93例T2DM患者作为研究对象，测量患者颈动脉内中膜厚度（IMT）、斑块情况。根据IMT值将选取T2DM患者分为3组：单纯糖尿病组32例（糖尿病组），糖尿病颈动脉内中膜增厚组31例（中膜增厚组），糖尿病颈动脉粥样硬化斑块形成组30例（斑块组）；另选健康查体者30名作为对照组。测定血清MMP-9浓度并进行相关分析。结果糖尿病组血清MMP-9为（550．26±269．28）μg／L，显著高于对照组（359．70±215．62）μg/L，差异有统计学意义（t=2．23，P〈0．05）；中膜增厚组MMP-9为（712．15±340．47）μg／L明显高于对照组（t=4．53，P〈0．01）和单纯糖尿病组（t=2．40，P〈0．05）；斑块组MMP-9为（889．08±247．80）μg／L明显高于对照组（t=7．01，P〈0．01）、糖尿病组（t=4．89，P〈0．01）和中膜增厚组（t=2．53，19〈0．05）。结论血清MMP-9升高与颈动脉粥样硬化的病变程度密切相关。Objective To investigated the relationship between serum matrix metalloproteinase-9 （MMP-9） and carotid atherosclerosis （AS） in type 2 diabetes mellitus （T2DM）. Methods A total of 93 patients with T2DM were recruited to our study. The intima-media thickness（IMT） and plaques of carotid artery were measured. These patients were divided into 3 groups according to their IMT values： diabetes mellitus （DM） group（ n = 32 ）, carotid artery intima thicken group （n = 31 ） and carotid artery intima plaque group （n = 30 ）. At the same time, 30 healthy individuals were selected as control. Serum level of MMP-9 were determined and analyzed. Results The serum MMP-9 in DM group was significantly higher than that in healthy controls （ [ 550. 26 ± 269. 28 ] μg/L vs. [ 359. 70 ± 215.62 ] μg/L, t = 2. 23, P 〈 0. 05 ）. The serum MMP-9 level of intima thicken group（712. 15±340. 47 ）μg/L was significantly higher than that in healthy controls （t = 4. 53, P 〈 0. 01 ） and DM group（ t = 2.40 ,P 〈 0. 05 ）. The serum MMP-9 level of plaque group（ [ 889. 08±247. 80 ] p.g/L） was even more significantly higher than DM group （ t = 4. 89, P 〈 0. 01 ）, IMT group （ t = 2. 53, P 〈 0.05 ） and healthy controls （ t = 7. 01, P 〈 0. 01 ）. Conclusion The severity of carotid atherosclerosis in T2DM is closely associated with the serum MMP-9 level.

关 键 词：基质金属蛋白酶-9 动脉粥样硬化 2型糖尿病 颈动脉内中膜厚度 大血管病变 

分 类 号：R587.1[医药卫生—内分泌] R543.4[医药卫生—内科学]