新诊断的2型糖尿病患者胰岛素强化治疗前后氧化应激水平的变化  

The effect of continuous subcutaneous insulin infusion on oxidative stress level in newly diagnosed type 2 diabetic patients

作　　者：黄海[1] 祝开思[1] 王平[1] 张世俊[2] 

机构地区：[1]中国人民解放军第305医院内分泌科,北京100017 [2]中国人民解放军第305医院全军老年病实验室中心,北京100017

出　　处：《中国糖尿病杂志》2011年第5期338-339,共2页Chinese Journal of Diabetes

摘　　要：目的评价新诊断的2型糖尿病(T2DM)患者胰岛素强化治疗前后氧化应激水平的变化。方法 30例新诊断的T2DM患者采用胰岛素泵强化治疗,治疗前后进行超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平测定。结果胰岛素泵强化治疗后,患者血浆中的SOD、GSH-Px水平明显上升(P<0.01)、MDA水平明显下降(P<0.01)。结论新诊断的T2DM患者胰岛素强化治疗后氧化应激水平明显降低。Objective To evaluate the effect of continuous subcutaneous insulin infusion （CSII） on oxidative stress level in newly diagnosed T2DM patients. Methods 30 newly diagnosed T2DM patients were treated with continuous subcutaneous insulin infusion. The levels of SOD, GSH-Px and MDA were measured after insulin pump therapy. Results After the treatment, SOD and GSH-Px had more significant improvement. Otherwise, MDA was significantly＇ decreased （ P 〈 0. 01 ）. Conclusions Oxidative stress level of newly diagnosed T2DM patients is significantly decreased after continuous subcutaneous insulin infusion treatment.

关 键 词：糖尿病 2型 胰岛素泵 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]