超声引导下罗哌卡因臂丛神经阻滞的半数有效浓度  

Median effective concentration of ropivacaine for ultrasound-guided brachial plexus block

作　　者：顾晨桃[1] 王爱忠[1] 单宇[1] 江伟[1] 

机构地区：[1]上海交通大学医学院附属上海市第六人民医院麻醉科,苏州大学临床医学院,200233

出　　处：《中华麻醉学杂志》2011年第2期217-219,共3页Chinese Journal of Anesthesiology

摘　　要：目的 超声引导下罗哌卡因臂丛神经阻滞的半数有效浓度.方法 择期上肢手术患者50例,年龄19～72岁,体重45～83 ks,身高150～181 cm,ASA分级Ⅰ或Ⅱ级.超声引导下行臂丛神经阻滞,定位成功后注入罗哌卡因30 ml,初始浓度0.50%,浓度变化梯度为O.05%,阻滞有效则下一例采用低一级浓度,阻滞无效,则下一例采用高一级浓度.采用Prebit法计算超声引导下罗哌卡因臂丛神经阻滞的半数有效浓度及其95%可信区间.结果 超声引导下罗哌卡因臂丛神经阻滞的半数有效浓度为0.436%,95%可信区间为0.393%～0.477%.结论 超声引导下罗哌卡因臂丛神经阻滞的半数有效浓度为0.436%.Objective To determine the median effective concentration （EC50） of ropivacaine for ultrasound-guided brachial plexus block.Methods Fifty ASA Ⅰ or Ⅱ patients of both sexes, aged 19-72 yr, weighing 45-83 kg, scheduled for upper extremity surgery under brachial plexus block guided by ultrasound, were enrolled in this study. Brachial plexus block was performed under the guidance of ultrasound. After successful location, ropivacaine 30 ml was injected. EC50 of ropivacaine was determined by up-and-down sequential method. The initial concentration was 0.50% . Each time the concentration increased/decreased by 0.05% . EC50 of ropivacaine required for ultrasound-guided brachial plexus block and 95% confidence interval were calculated using Probit analysis.Results The EC50 of ropivacaine resulting in complete block of the brachial plexus nerve was 0.436%（95% confidence interval 0.393%-0.477% ）. Conclusion The EC50 of ropivacaine is 0.436% for ultrasoundguided brachial plexus block.

关 键 词：酰胺类 剂量效应关系 药物 臂丛 神经传导阻滞 超声检查 

分 类 号：R614[医药卫生—麻醉学]