纳米颗粒在人类鼻腔中沉降率的研究  

RESEARCH ON THE DEPOSITION EFFICIENCY OF NANOPARTICLE IN HUMAN NASAL CAVITY

作　　者：赵晓东[1] 张凯[2] 田福真[2] 

机构地区：[1]中国计量学院热能工程研究所,杭州310018 [2]中国计量学院流体工程与仿真研究所,杭州310018

出　　处：《力学学报》2011年第3期482-487,共6页Chinese Journal of Theoretical and Applied Mechanics

基　　金：国家自然科学基金(10902105);浙江省自然科学基金(Y6090406);浙江省科技计划(2009C31164;2010R10014)资助项目~~

摘　　要：借助欧拉和拉格朗日方法数值模拟了纳米颗粒在人类鼻腔中的输运和沉降.在采用有限体积法以及k-w湍流模型求解流场的基础上,通过单向耦合的拉格朗日方法得出了水动力、热泳力和布朗力等综合作用下的纳米颗粒的运动轨迹以及沉降率.研究发现,非常微小的纳米颗粒在鼻腔内的沉降率非常高;粒径在1～10 nm的纳米颗粒在鼻腔中的沉降率从80%降至18%;粒径在10～150 nm之间的纳米颗粒在鼻腔中的沉降率变化很小,且其值介于15%～18%之间.The Eulerian and Lagrangian method are used to numerically simulate the transport and deposition of nanoparticle in human nasal cavity with finite volume method.The k-w turbulence model is used to get the flow field,and one-way coupling Lagrangian method is used to track the trajectory of nanoparticle with Stokes, Brownian and thermophoretic force considered in this model.It＇s found that Deposition in the nasal cavity is high for very small nanoparticles.The particle diameter range in which the deposition drops from 80%to 18% is between 1nm and 10 nm.From 10 nm to 150 nm however,there is only a small change in the deposition curve from 18%to 5%.These results are helpful to develop the medicine the disease of human nasal cavity.

关 键 词：纳米颗粒 鼻腔 沉降 数值模拟 

分 类 号：TB126[理学—工程力学]