注射用头孢尼西钠与果糖注射液的配伍稳定性考察  

Compatible Stability of Cefonicid Sodium for Injection with Fructose Injection

作　　者：惠慧[1] 韩强[1] 

机构地区：[1]徐州医学院附属医院药剂科,徐州市221002

出　　处：《中国药房》2011年第22期2061-2062,共2页China Pharmacy

摘　　要：目的:考察注射用头孢尼西钠在室温(25±1)℃下与果糖注射液配伍的稳定性。方法:模拟临床用药浓度,将注射用头孢尼西钠1.0g加入到10mL果糖注射液中,混合均匀后,在室温(25±1)℃下考察6h内配伍液的外观和pH值变化,并采用高效液相色谱法测定头孢尼西的含量,同时考察有无新物质生成。结果:在室温(25±1)℃下,0～6h配伍液的外观、pH值、头孢尼西的含量均无明显变化。结论:注射用头孢尼西钠与果糖注射液配伍,在室温(25±1)℃下6h内配伍稳定。OBJECTIVE： To investigate the compatible stability of Cefonicid sodium for injection with Fructose injection at room temperature （25±1）℃. METHODS： At room temperature （25±1）℃, Cefonicid sodium for injection 1.0 g was added into 10 mL Fructose injection. The appearance and pH value of mixture in 6 h were observed. The content of cefonicid was determined by HPLC, and whether new matter generated was investigated. RESULTS： At room temperature （25±1）℃, there were no changes in appearance, pH value and cefonicid sodium concentration of mixture within 0～6 h. CONCLUSION： At room temperature （25±1）℃, the compatibility of Cefonicid sodium for injection combined with Fructose injection is stable within 6h.

关 键 词：注射用头孢尼西钠 果糖注射液 配伍 稳定性 高效液相色谱法 

分 类 号：R978.11[医药卫生—药品] R969.2[医药卫生—药学]