头孢米诺致药品不良反应文献分析  

Analysis of Adverse Drug Reactions Induced by Cefminox

作　　者：龙敏[1] 陈蓉 王颖[3] 

机构地区：[1]成都市第六人民医院,成都市610051 [2]成都市木综厂职工医院,成都市610081 [3]四川省食品药品检验所,成都市610097

出　　处：《中国药房》2011年第22期2077-2079,共3页China Pharmacy

摘　　要：目的:探讨头孢米诺致药品不良反应(ADR)发生的特点及规律。方法:检索1990-2010年"中国医药期刊全文数据库"中有关头孢米诺临床应用及ADR个案报道的文献,得到符合条件的文献35篇共1474例,其中临床应用23篇1449例,个案报道12篇25例,并进行统计、分析、评价。结果:临床应用文献中,有84例记载ADR并分类,ADR发生率为5.80%,主要表现为消化系统反应(71.43%)、皮肤及其附件损害(19.05%)等。ADR个案报道为:急性肾损害(32.00%)、凝血障碍(20.00%)、皮肤及其附件损害(16.00%)等;以60岁以上的老年患者发生率最高(60.00%),约80.00%的ADR出现在用药3d后。结论:临床应重视头孢米诺引起的ADR,用药时应加强对患者的监护,以减少严重ADR的发生。OBJECTIVE： To investigate the characteristics and regularity of ADR induced by cefminox. METHODS： ADR case reports and literatures about application of cefminox were retrieved from CHKD during 1990-2010. A total of 35 related literatures involving 1 474 cases, in which there were 23 literatures about clinical application of 1 449 cases and 12 individual case reports of 25 cases were analyzed statistically. RESULTS： Among literatures about clinical application, there were 84 ADR cases and the incidence of ADR was 5.80%. The main clinical manifestation represented as digestive system（71.43%）and lesion of skin and its appendants（19.05%）. In 25 individual cases, it was reported that acute kidney injury accounted for 32.00%, coagulation disorders accounted for 20.00%, lesion of skin and its appendants accounted for 16.00%. 60.00% were occurred in the patients aged over 60, 80.00% occurred after 3 days of medication. CONCLUSION： It is necessary to pay attention to ADR induced by cefminox in the clinic and strengthen observation during medication in order to reduce the serious ADR.

关 键 词：头孢米诺 药品不良反应 文献 分析 

分 类 号：R969.3[医药卫生—药理学]