功能失调性子宫出血的相关分子机制的研究进展  

Research Advancement in Molecular Mechanisms of Dysfunctional Uterine Bleeding

作　　者：孙燕[1] 袁媛[1] 蒋晓莉[1] 

机构地区：[1]广西医科大学第一附属医院妇产科,南宁530021

出　　处：《医学综述》2011年第10期1481-1483,共3页Medical Recapitulate

摘　　要：功能失调性子宫出血(DUB)是妇科内分泌疾病,临床表现为非器质性病变引起的异常子宫出血,严重危害妇女健康,近年来其发病率有逐年上升的趋势。其发病机制不明,可能与调节生殖的神经内分泌机制失常所致的子宫内膜微环境异常有关。现对子宫内膜的血管功能、性激素及其受体,细胞凋亡及基质金属蛋白酶在DUB中的研究进展予以综述。Dysfunctional uterine bleeding（DUB） is a gynecological endocrine disease,which clinically manifests mainly as non-organic abnormal uterine bleeding.DUB compromises women′s health and with an annually increasing incidence.The etiology of DUB remains unknown,possibly associated with the abnormal uterine microenvironment disorders caused by the neuroendocrine malfunction.This article reviews endometrial vascular function,sex hormones and receptors,apoptosis,and matrix metalloproteinases in the sense of the pathogenesis of DUB.

关 键 词：功能失调性子宫出血 血管功能 性激素 细胞凋亡 基质金属蛋白酶 

分 类 号：R711.5[医药卫生—妇产科学]